Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 306, Issue 1, pp 61–66 | Cite as

Relation between the thermoregulatory effects of intracerebroventricularly injected dopamine and 5-hydroxytryptamine in the rabbit

  • Th. A. J. M. de Roij
  • J. Frens
  • M. Vianen-Meijerink
  • F. Woutersen-van Nijnanten
Article

Summary

The thermoregulatory effects of dopamine (DA, 400 μg), injected intracerebroventricularly (i.c.v.) in rabbits, were investigated at different ambient temperatures (Ta). The effects at 20° C Ta were compared with those of 5-hydroxytryptamine (5-HT, 200 μg) and noradrenaline (NA, 200 μg).

At 20° C Ta DA induced a dilatation of the ear vessels but did not change rectal temperature (Tr). I.c.v. injection of 5-HT induced panting and fall in Tr while after NA a rise in Tr and constriction of the ear vessels were observed. At 32° C Ta no change in Tr was observed after DA. At 5° C Ta DA caused a short-lasting decrease in Tr.

After treatment with the DA antagonist haloperidol (400 μg, i.c.v.) a hypothermia was observed after DA at 20° C Ta. Haloperidol did not influence the response after 5-HT or NA.

The 5-HT antagonist methysergide (500 μg, i.c.v.) blocked panting and the hypothermia normally caused by i.c.v. 5-HT at 20° C Ta; instead of decreasing, Tr tended to increase after 5-HT. After pretreatment with methysergide Tr rose immediately after i.c.v. injection of DA.

These results suggest that the hypothermia after i.c.v. DA in the rabbit is secondarily mediated by serotonergic structures in the pathway between heat sensors and heat loss effectors. The hyperthermic effect of i.c.v. DA, which showed after pretreatment with methysergide and was apparently blocked by haloperidol, is probably the result of an activation of DA receptors in the pathway from cold sensors to heat production effectors. The hyperthermia after i.c.v. NA could be due to an inhibition of the heat loss pathway.

Key words

Dopamine 5-Hydroxytryptamine Central thermoregulation Methysergide Rabbit Haloperidol 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bligh, J., Cottle, W. H.: The influence of ambient temperature on thermoregulatory responses to intraventricularly injected monoamines in sheep, goats and rabbits. Experientia 25, 608–609 (1969)Google Scholar
  2. Bligh, J., Cottle, W. H., Maskrey, M.: Influence of ambient temperature on the thermoregulatory responses to 5-hydroxytryptamine, noradrenaline and acetylcholine injected into the lateral cerebral ventricles of sheep, goats and rabbits. J. Physiol. (Lond.) 212, 377–392 (1971)Google Scholar
  3. Cools, A. R., Struycker Boudier, H. A. J., van Rossum J. M.: Dopamine receptors: Selective agonists and antagonists of functionally distinct types within the feline brain. Eur. J. Pharmac. 37, 283–293 (1976)Google Scholar
  4. Cooper, K. E., Cranston, W. I., Honour, A. J.: Effects of intraventricular and intrahypothalamic injection of noradrenaline and 5-HT on body temperature in conscious rabbits. J. Physiol. (Lond.) 181, 852–864 (1965)Google Scholar
  5. Dhawan, B. N., Dua, P. R.: Evidence for the presence of α-adrenoceptors in the central thermoregulatory mechanism of the rabbit. Br. J. Pharmac. 43, 497–503 (1971)Google Scholar
  6. Frens, J.: Central synaptic interference and experimental fever. Int. J. Biometeor. 15, 313–315 (1971)Google Scholar
  7. Frens, J.: Pharmacological evidence for a set-point mechanism inthermoregulation. In: Drugs, biogenic amines and body temperature. Cooper, K. E., Lomax, P., Schönbaum, E. (eds.), pp. 20–25. Basel: Karger 1977Google Scholar
  8. Girault, J. M., Kandasamy, B., Jacob, J.: Actions centrales des amines catéchiques sur la température du lapin éveillé. Antagonismes par des adrénolitiques α et β. J. Pharmac. (Paris) 5, 343–362 (1974)Google Scholar
  9. Girault, J. M., Kandasamy, B., Jacob, J.: Actions de divers neuroleptiques sur les hyperthermies centrales induites par la dopamine, la noradrénaline et la 5-hydroxytryptamine chez le lapin éveillé. J. Pharmac. (Paris) 6, 341–350 (1975)Google Scholar
  10. Grabowska, M., Michaluk, J., Antkiewicz, L.: Possible involvement of brain serotonin in apomorphine-induced hypothermia. Eur. J. Pharmac. 23, 82–89 (1973)Google Scholar
  11. Grabowska, M., Michaluk, J., Antkiewicz, L.: Pharmacological effects of apomorphine in rats with altered level of brain serotonin. Arch. Immun. Ther. Exp. (Warsz.) 23, 517–526 (1975)Google Scholar
  12. Hill, H. F., Horita, A.: A pimozide-sensitive effect of apomorphine on body temperature of the rabbit. J. Pharm. Pharmac. 24, 490–491 (1972)Google Scholar
  13. Jacob, J., Girault, J. M.: The influence of cyproheptadine and of d-lysergamide on the rise in temperature induced by intraventricular 5-hydroxytryptamine, noradrenaline and dopamine in conscious rabbits. Eur. J. Pharmac. 27, 59–67 (1974)Google Scholar
  14. Jacob, J., Peindaris, R.: Central effects of monoamines on the temperature of the conscious rabbit. In: The pharmacology of thermoregulation. Schönbaum, E. and Lomax, P. (eds.), pp. 202–216. Basel: Karger 1973Google Scholar
  15. Jacob, J., Girault, J. M., Peindaris, R.: Actions of5-hydroxytryptamine and 5-hydroxytryptophan injected by various routes on the rectal temperature of the rabbit. Neuropharmac. 11, 1–16 (1972)Google Scholar
  16. Kostowski, W.: Interactions between serotonergic and catecholaminergic system in the brain. Pol. J. Pharmac. Pharm. 27, suppl., 15–24 (1975)Google Scholar
  17. Maj, J.: The influence of dopaminergic agents on the serotonergic neurons. Pol. J. Pharmac. Pharm. 27, suppl., 45–47 (1975)Google Scholar
  18. Milton, A. S., Harvey, C. A.: Prostaglandins and monoamines in fever. In: Temperature regulation and drug action, Lomax, P., Schönbaum, E., Jacob, J. (eds.), pp. 133–142. Basel: Karger 1975Google Scholar
  19. Mogilnicka, E., Scheel-Krüger, J. J., Klunik, V., Golembiowska-Nikitin, K.: The influence of antiserotonergic agents on the action of dopaminergic drugs. Pol. J. Pharmac. Pharm. 29, 31–38 (1977)Google Scholar
  20. Przewlocki, R.: Dopaminergic and serotonergic mechanisms of hypothermia induced by dopamine agonists. Naunyn-Schmiedeberg's Arch. Pharmacol. 294, 16R (1976)Google Scholar
  21. Quock, R. M., Horita, A.: Apomorphine: modification of its hyperthermic effect in rabbits by p-chlorophenylalanine. Science 183, 539–540 (1974)Google Scholar
  22. Quock, R. M., Horita, A.: Differentiation of neuropharmacological actions of apomorphine and d-amphetamine. Pharmac. Biochem. Behav. 5, 627–631 (1976)Google Scholar
  23. Quock, R. M., Carino, M. A., Chesnut, R. M., Weick, B. G., Beal, G. A., Horita, A.: Apomorphine: antagonism of its hyperthermic action in the rabbit by intracerebrally administered haloperidol. Proc. West. Pharmac. Soc. 18, 41–42 (1975)Google Scholar
  24. Roij, Th. A. J. M. de, Frens, J., Bakker, J., Németh, F.: Thermoregulatory effects of intraventricularly injected dopamine in goats. Eur. J. Pharmac. 43, 1–7 (1977)Google Scholar
  25. Roij, Th. A. J. M. de, Frens, J., Woutersen-van Nijnanten, F., Vianen-Meijerink, M.: Comparison of the thermoregulatory responses to intracerebroventricularly injected dopamine, noradrenaline and 5-hydroxytryptamine in the goat. Eur. J. Pharmac. (in press, 1978)Google Scholar
  26. Ruckebusch, Y., Grivel, M. C., Laplace, J. P.: Variations terspcifiques des modifications de la température centrale liées à l'injection intracérébroventriculaire de catécholamines et de 5-hydrotryptamine. C. R. Soc. Biol. 159, 1748–1750 (1965)Google Scholar
  27. Sawyer, C. H., Everett, J. W., Green, J. D.: The rabbit diencephalon in stereotaxic coordinates. J. Comp. Neurol. 101, 801–824 (1954)Google Scholar
  28. Struycker Boudier, H. A. J., Gielen, W., Cools, A. R., van Rossum, J. M.: Pharmacological analysis of dopamine-induced inhibition and excitation of neurones of the snail Helix aspera. Arch. int. Pharmacodyn. 209, 324–332 (1974)Google Scholar
  29. Tangri, K. K., Bhargava, A. K., Bhargava, H. P.: Interrelation between monoaminergic and cholinergic mechanisms in the hypothalamic thermoregulatory center of rabbits. Neuropharma. 13, 333–346 (1974)Google Scholar

Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • Th. A. J. M. de Roij
    • 1
  • J. Frens
    • 1
  • M. Vianen-Meijerink
    • 1
  • F. Woutersen-van Nijnanten
    • 1
  1. 1.Institute of Veterinary Pharmacology and ToxicologyUtrecht UniversityUtrechtThe Netherlands

Personalised recommendations