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Synthesis of Ftorafur (review)

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Published data on methods for the synthesis of the antitumor compound “Ftorafur” by the tetrahydrofurylation of 5-fluorouracil and its derivatives and also by fluorination, cyclization, solvolysis, oxidation, and other reactions are reviewed.

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  1. Institute of Organic Synthesis, Latvian Academy of Sciences, Riga

    É. Lukevits & A. Zablotskaya

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1590–1620, December, 1991.

The authors thank T. Shidlovskaya for assitance in the compilation of the tables.

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Lukevits, É., Zablotskaya, A. Synthesis of Ftorafur (review). Chem Heterocycl Compd 27, 1271–1299 (1991). https://doi.org/10.1007/BF00515572

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