Chemistry of Heterocyclic Compounds

, Volume 19, Issue 11, pp 1175–1179 | Cite as

Synthesis and reactions of 2-amino-3-(ω-chloroaklyl)indoles

  • Yu. N. Portnov
  • V. G. Zabrodnyaya
  • V. G. Voronin
  • A. N. Kost
Article
  • 27 Downloads

Abstract

The reaction of N-methyl-N-phenyl-N′-(ω-chloro)acylhydrazines with POC13 yields derivatives of 2-amino-3-(ω)-chloroalkyl) indoles. Hydrazides of β-chloropropionic acid were found to exist as the cyclic quaternary 3-oxopyrazolidinium salt. Several reactions involving the nucleophilic substitution of the chlorine atom in N-acylated derivatives of 2-aminoindole were studied.

Keywords

Organic Chemistry Chlorine Indole Hydrazide Chlorine Atom 

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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Yu. N. Portnov
    • 1
  • V. G. Zabrodnyaya
    • 1
  • V. G. Voronin
    • 1
  • A. N. Kost
    • 1
  1. 1.Branch of the S. Ordzhonikidze All-Union Pharmaceutical Chemistry Research InstituteKupavna

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