Chemistry of Heterocyclic Compounds

, Volume 22, Issue 3, pp 265–267 | Cite as

Nucleophilic substitution reactions in 4-halonitro-pyrazolecarboxylic acids

  • Yu. A. Manaev
  • V. P. Perevalov
  • M. A. Andreeva
  • B. I. Stepanov


The reaction of 4-bromo-1-methyl-3-nitropyrazole-5- and 4-bromo-1-methyl-5-nitro-pyrazole-3-carboxylic acids with arylamines in aqueous solution in the presence of monovalent copper salts leads to the formation of 4-arylamino- and 4-hydroxy substituted nitropyrazolecarboxylic acids.


Copper Aqueous Solution Organic Chemistry Nucleophilic Substitution Substitution Reaction 
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Literature cited

  1. 1.
    A. N. Kost and I. I. Grandberg, Adv. Heterocycl. Chem., 6, 347 (1966).Google Scholar
  2. 2.
    M. D. Coburn, J. Heterocycl. Chem., 8, 153 (1971).Google Scholar
  3. 3.
    C. G. Newton, W. D. Ollis, and D. E. Wright, J. Chem. Soc., Perkin 1, 63 (1984).Google Scholar
  4. 4.
    R. G. Johnes, J. Amer. Chem. Soc., 71, 3994 (1949).Google Scholar
  5. 5.
    M. A. Khan and A. A. Pinto, J. Heterocycl. Chem., 18, 9 (1981).Google Scholar
  6. 6.
    S. F. Vasilevskii, E. M. Rubinshtein, and M. S. Shvartsberg, Izv. Akad. Nauk SSSR, Ser. Khim., 1175 (1978).Google Scholar
  7. 7.
    Yu. A. Manaev, V. P. Perevalov, M. A. Andreeva, and B. I. Stepanov, Khim. Geterotsikl. Soed., No. 8, 1123, (1984).Google Scholar
  8. 8.
    E. S. Krongaus, D. A. Bochvar, I. V. Stankevich, and V. V. Korshak, Dokl. Akad. Nauk SSSR, Ser. Khim, 179, 94 (1968).Google Scholar
  9. 9.
    Yu. A. Manaev, M. A. Andreeva, V. P. Perevalov, and B. I. Stepanov, Zh. Org. Khim., 52, 2592 (1982).Google Scholar

Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • Yu. A. Manaev
    • 1
  • V. P. Perevalov
    • 1
  • M. A. Andreeva
    • 1
  • B. I. Stepanov
    • 1
  1. 1.D. I. Mendeleev Chemical Technology InstituteMoscow

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