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Chemistry of Heterocyclic Compounds

, Volume 20, Issue 5, pp 529–536 | Cite as

Synthesis of 5-hydroxy- and 5-acylhydrazinopyrazolidines by the reaction of β-substituted hydrazides with α,β-unsaturated aldehydes and their biological activity

  • K. N. Zelenin
  • A. V. Dovgilevich
  • I. P. Bezhan
  • G. A. Golubeva
  • L. A. Sviridova
  • L. V. Pastushenkov
  • É. G. Gromova
  • T. A. Gatchina
  • S. V. Pomogaibo
Article

Abstract

The reaction of β-substituted hydrazides with alkenals (acrolein, methacrolein, crotonaldehyde, and cinnamaldehyde) serves as a method for the synthesis of the corresponding 1-acyl-5-hydroxypyrazolidines and, in a number of cases, 1-acyl-5-acylhydrazinopyrazolidines. Some of the 1-acyl-5-hydroxypyrazolidines obtained have antiphlogistic activity.

Keywords

Organic Chemistry Aldehyde Biological Activity Hydrazide Acrolein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • K. N. Zelenin
    • 1
    • 2
    • 3
  • A. V. Dovgilevich
    • 1
    • 2
    • 3
  • I. P. Bezhan
    • 1
    • 2
    • 3
  • G. A. Golubeva
    • 1
    • 2
    • 3
  • L. A. Sviridova
    • 1
    • 2
    • 3
  • L. V. Pastushenkov
    • 1
    • 2
    • 3
  • É. G. Gromova
    • 1
    • 2
    • 3
  • T. A. Gatchina
    • 1
    • 2
    • 3
  • S. V. Pomogaibo
    • 1
    • 2
    • 3
  1. 1.S. M. Kirov Military Medical AcademyLeningrad
  2. 2.M. V. Lomonosov Moscow State UniversityMoscow
  3. 3.Leningrad Institute of Pharmaceutical ChemistryLeningrad

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