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Chemistry of Heterocyclic Compounds

, Volume 20, Issue 8, pp 838–841 | Cite as

Acetylation, bromination, and nitration of benzoxaheterocycles and synthesis of β-aminoketones from acetyl derivatives

  • V. K. Daukshas
  • O. Yu. Pyatrauskas
  • É. B. Udrenaite
  • P. G. Gaidyalis
  • G. A. Gasperavichene
Article

Abstract

The method of competing reactions was used to establish the sequence of variation of the relative rates of acetylation, bromination, and nitration reactions of 2-methylcoumaran, chroman, 2,3,4,5-tetrahydrobenzo-1-oxepan, and 1-methoxy-2-ethylbenzene. The isomeric composition of the substitution products formed was determined. The acetyl derivatives were converted according to a Mannich reaction to hydrochlorides of β-dimethylaminopropionyl derivatives, possessing antiinflammatory activity.

Keywords

Chroman Organic Chemistry Hydrochloride Acetyl Antiinflammatory Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • V. K. Daukshas
    • 1
  • O. Yu. Pyatrauskas
    • 1
  • É. B. Udrenaite
    • 1
  • P. G. Gaidyalis
    • 1
  • G. A. Gasperavichene
    • 1
  1. 1.V. Kapsukas Vil'nyus State UniversityVil'nyus

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