Chemistry of Heterocyclic Compounds

, Volume 20, Issue 8, pp 838–841 | Cite as

Acetylation, bromination, and nitration of benzoxaheterocycles and synthesis of β-aminoketones from acetyl derivatives

  • V. K. Daukshas
  • O. Yu. Pyatrauskas
  • É. B. Udrenaite
  • P. G. Gaidyalis
  • G. A. Gasperavichene


The method of competing reactions was used to establish the sequence of variation of the relative rates of acetylation, bromination, and nitration reactions of 2-methylcoumaran, chroman, 2,3,4,5-tetrahydrobenzo-1-oxepan, and 1-methoxy-2-ethylbenzene. The isomeric composition of the substitution products formed was determined. The acetyl derivatives were converted according to a Mannich reaction to hydrochlorides of β-dimethylaminopropionyl derivatives, possessing antiinflammatory activity.


Chroman Organic Chemistry Hydrochloride Acetyl Antiinflammatory Activity 
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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • V. K. Daukshas
    • 1
  • O. Yu. Pyatrauskas
    • 1
  • É. B. Udrenaite
    • 1
  • P. G. Gaidyalis
    • 1
  • G. A. Gasperavichene
    • 1
  1. 1.V. Kapsukas Vil'nyus State UniversityVil'nyus

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