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Pyrimidine derivatives. 56. New method for the synthesis of thieno[2,3-d]pyrimidine

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

A new scheme was developed for the synthesis of 2,4-dimethy1-5,6-dihydro-6-bromomethylthieno[2,3-d]pyrimidine by bromination of the corresponding 5-allyl-6-mercaptopyrimidine. It is shown that when the bromomethyl derivative is treated with sodium methoxide a molecule of hydrogen bromide is split out to give 2,4,6-trimethylthieno[2,3-d]pyrimidine. The structures of the synthesized compounds were proved by PMR spectroscopy and mass spectrometry.

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Literature cited

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Authors and Affiliations

  1. Institute of Fine Organic Chemistry, Academy of Sciences of the Armenian SSR, 375014, Erevan

    R. G. Melik-Ogandzhanyan, A. S. Gapoyan, V. É. Khachatryan & V. S. Mirzoyan

Authors
  1. R. G. Melik-Ogandzhanyan
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  2. A. S. Gapoyan
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  3. V. É. Khachatryan
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  4. V. S. Mirzoyan
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Additional information

See [1] for Communication 55.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 118–120, January, 1982.

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Melik-Ogandzhanyan, R.G., Gapoyan, A.S., Khachatryan, V.É. et al. Pyrimidine derivatives. 56. New method for the synthesis of thieno[2,3-d]pyrimidine. Chem Heterocycl Compd 18, 100–102 (1982). https://doi.org/10.1007/BF00513299

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  • DOI: https://doi.org/10.1007/BF00513299

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