Chemistry of Heterocyclic Compounds

, Volume 19, Issue 1, pp 103–106 | Cite as

Synthesis of indole derivatives of pyrido[2,3-d]pyrimidine

  • T. V. Stupnikova
  • T. V. Nuzhnaya
  • N. A. Klyuev
  • A. Yu. Chervinskii
Article
  • 43 Downloads

Abstract

Recyclization of the pyrimidine ring with inclusion of the reagent in the newly formed ring to give indole derivatives of 2,3-disubstituted pyridines occurs in the reaction of the anhydro base of 4-(3-indolyl)pyrimidine with CH acids in the presence of triethylamine. The products react with formamide to give the pyrido[2,3-d]pyrimidine heterocyclic system.

Keywords

Organic Chemistry Pyridine Indole Pyrimidine Formamide 

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Literature cited

  1. 1.
    A. K. Sheinkman, V. P. Marshtupa, N. M. Shneer, L. G. Sharanina, and V. V. Petrenko, Khim. Geterotsikl. Soedin., No. 1, 132 (1978).Google Scholar
  2. 2.
    Kh. Ya. Lopatinskaya, A. K. Sheinkman, T. V. Stupnikova, N. A. Klyuev, and A. N. Krasovskii, Khim. Geterotsikl. Soedin., No. 5, 675 (1979).Google Scholar
  3. 3.
    T. V. Stupnikova, T. V. Nuzhnaya, N. A. Klyuev, and A. Yu. Chervinskii, Khim. Geterotsikl. Soedin., No. 2, 212 (1982).Google Scholar
  4. 4.
    Yu. A. Sharanin and V. K. Promonenko. Izv. Sibirsk. Otd. Akad. Nauk SSSR, Ser. Khim., No. 2, 80 (1980).Google Scholar
  5. 5.
    N. A. Klyuev, T. V. Stupnikova, S. N. Baranov, and P. B. Kurapov, Dokl. Akad. Nauk Ukr. SSR, Ser. B, No. 9, 47 (1980).Google Scholar
  6. 6.
    D. V. Ramana and M. Vairamani, Org. Mass Spectrom., 14, No. 2, 98 (1978).Google Scholar
  7. 7.
    A. A. Polyakov and R. A. Khmel'nitskii, Mass Spectrometry in Organic Chemistry [in Russian], Khimiya, Leningrad (1972), p. 127.Google Scholar

Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • T. V. Stupnikova
    • 1
  • T. V. Nuzhnaya
    • 1
  • N. A. Klyuev
    • 1
  • A. Yu. Chervinskii
    • 1
  1. 1.Donetsk State UniversityDonetsk

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