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The deamination of noradrenaline and 5-hydroxytryptamine by rat brain and heart monoamine oxidase and their inhibition by cimoxatone, toloxatone and MD 770222

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Summary

In both rat brain and heart, noradrenaline and 5-hydroxytryptamine are metabolised predominantly by monoamine oxidase-A. The K m values for 14C-noradrenaline in the rat brain and heart are 290 μM and 300 μM, respectively, whereas for 14C-5-hydroxytryptamine the values are 180 μM and 140 μM, respectively. In the rat brain, mixed substrate experiments suggested that 14C-noradrenaline and 14C-5-hydroxytryptamine are metabolised at the same active centre. Both substrates are inhibited with similar K i values by the reversible inhibitors cimoxatone, toloxatone and MD 770222.

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Author notes

  1. Christopher J. Fowler

    Present address: Astra Läkemedel AB, S-151 85, Södertälje, Sweden

Authors and Affiliations

  1. Centre de Recherche Delalande, 10 rue des Carrières, F-92500, Rueil-Malmaison, France

    Margherita Strolin Benedetti, Thierry Boucher & Christopher J. Fowler

Authors
  1. Margherita Strolin Benedetti
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  2. Thierry Boucher
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  3. Christopher J. Fowler
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Benedetti, M.S., Boucher, T. & Fowler, C.J. The deamination of noradrenaline and 5-hydroxytryptamine by rat brain and heart monoamine oxidase and their inhibition by cimoxatone, toloxatone and MD 770222. Naunyn-Schmiedeberg's Arch. Pharmacol. 323, 315–320 (1983). https://doi.org/10.1007/BF00512469

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  • DOI: https://doi.org/10.1007/BF00512469

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