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Differential blockade by (−)mianserin of the alpha2-adrenoceptors mediating inhibition of noradrenaline and serotonin release from rat brain synaptosomes

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Summary

Mianserin and its two enantiomers were studied as antagonists of the alpha2-adrenoceptors mediating inhibition of noradrenaline and 5-hydroxytryptamine release in rat brain cortex. The inhibitory effect of exogenous noradrenaline on the release of 3H-noradrenaline evoked by 15 mM KCl from superfused cortical synaptosomes was antagonized by racemic mianserin and by (+)mianserin; the (−)enatiomer was ineffective. In contrast, both (+)mianserin and (−)mianserin antagonized the inhibitory effect of noradrenaline on the release of 3H-5-hydroxytryptamine. The results suggest that the alpha2-autoreceptors on noradrenergic nerve endings differ from the alpha2-adrenoceptors located on serotoninergic terminals.

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Authors and Affiliations

  1. Istituto di Farmacologia e Farmacognosia, Università di Genova, Via Capo S. Chiara 5, I-16146, Genova, Italy

    Maurizio Raiteri, Guido Maura, Anita Gemignani & Anna Pittaluga

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  1. Maurizio Raiteri
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  2. Guido Maura
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  3. Anita Gemignani
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  4. Anna Pittaluga
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Raiteri, M., Maura, G., Gemignani, A. et al. Differential blockade by (−)mianserin of the alpha2-adrenoceptors mediating inhibition of noradrenaline and serotonin release from rat brain synaptosomes. Naunyn-Schmiedeberg's Arch. Pharmacol. 322, 180–182 (1983). https://doi.org/10.1007/BF00512394

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  • DOI: https://doi.org/10.1007/BF00512394

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