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Determination of residual solvents in a transdermal system by means of headspace gas chromatography

Bestimmung von Restlösungsmittelgehalten in einem transdermalen System durch Headspace-Gas-Chromatographie

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Zusammenfassung

Pharmazeutische Produkte müssen auf Verunreinigungen geprüft werden, auch auf Restlösungsmittelgehalte. Ein zusätzlicher Grund ist die fortlaufende Kontrolle der Herstellung. Die einfachste Möglichkeit für dieses Problem ist die Bestimmung durch Headspace-Gas-Chromatographie. Dieser Artikel beschreibt die Bestimmung von noch vorhandenen flüchtigen Kohlenwasserstoffen in dem transdermalen System DEPONIT durch nur eine Headspace-Messung. Die Richtigkeit ist durch die Anwendung der Mehrfach-Gasextraktionstechnik sichergestellt.

Summary

Pharmaceutical products have to be tested for impurities including residual solvents. This is also required in production control. The simplest solution to this problem is headspace gas chromatography. This paper describes the determination of residual volatile hydrocarbons in the transdermal system DEPONIT by only one headspace measurement. Accuracy is ensured by the multiple headspace extraction technique.

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Authors and Affiliations

  1. Schwarz GmbH, Mittelstrasse 11-13, D-4019, Monheim, Federal Republic of Germany

    Heinfried Grote & Günter Leugers

Authors
  1. Heinfried Grote
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  2. Günter Leugers
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Grote, H., Leugers, G. Determination of residual solvents in a transdermal system by means of headspace gas chromatography. Z. Anal. Chem. 327, 782–785 (1987). https://doi.org/10.1007/BF00511907

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  • DOI: https://doi.org/10.1007/BF00511907

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