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Suppression of isoprenaline-induced increase in plasma renin concentration by vasoconstrictors in rats with nonfunctioning Macula densa

  • D. K. Meyer
  • G. Hertting
  • Ch. Mittermayer
Short Communication

Summary

The mechanism of the increase in plasma renin concentration caused by the β-sympathomimetic agent isoprenaline has been further investigated.

Rats were pretreated by occluding the left renal artery for 2 hrs, thus rendering the macula densa cells of this kidney nonfunctioning. After contralateral nephrectomy infusion of isoprenaline (1.5 μg/kg min) still caused a strong increase in plasma renin concentration. This increase was significantly suppressed by simultaneous infusion of angiotensin II (1.0 μg/kg min), the α-sympathomimetic amine phenylephrine (60 μg/kg min) or octapressin (10 mU/kg min). The results exclude any mediator-role of the macula densa receptors in the isoprenaline-induced release of renin.

The possibility of a stimulation of renin release via the baroreceptors or a direct “secretomotoric” action of isoprenaline is discussed.

Key words

Isoprenaline Renin Vasoconstrictors Macula densa 

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References

  1. Aoi, W., Wade, M. B., Rosner, D. R., Weinberger, M. H.: Renin release by rat kidney slices in vitro: effects of cations and catecholamines. Amer. J. Physiol. 227, 630–634 (1974)Google Scholar
  2. Assaykeen, T. A., Tanigawa, H.: The effect of phentolamine, d-propranolol and dl-propranolol on the renin response to isoproterenol in dogs. Fed. Proc. 31, 511 (1972)Google Scholar
  3. Ayers, C. R., Harris, R. H., Lefer, L. G.: Control of renin release in experimental hypotension. Circulat. Res. 24, Suppl. I, 103–112 (1969)Google Scholar
  4. Blaine, E. H., Davis, J. O., Witty, R. T.: Renin release after hemorrhage and after suprarenal aortic constriction in dogs without sodium delivery to the macula densa. Circulat. Res. 27, 1081–1089 (1970)Google Scholar
  5. Fülgraff, G., Heidenreich, O., Heintze, K., Osswald, H.: Die Wirkung von α- und β-Sympathomimetica und Sympatholytica auf die renale Exkretion und Resorption von Flüssigkeit und Elektrolyten in Ausscheidungs-und Mikropunktionsversuchen an Ratten. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 262, 295–308 (1969)Google Scholar
  6. Greven, J.: Evidence for redistribution of filtrate among nephrons after β-adrenergic stimulation and blockade. Naunyn-Schmiedeberg's Arch. Pharmacol. 282, 171–180 (1974)Google Scholar
  7. Gross, F., Brunner, H., Ziegler, M.: Renin-angiotensin system, aldosterone and sodium balance. Recent Progr. Hormone Res. 21, 119–123 (1965)Google Scholar
  8. Hofbauer, K. G., Zschiedrich, M., Schwarz, K., Gross, F.: Effects of isoproterenol on renal function and renin release in the isolated perfused rat kidney. Naunyn-Schmiedeberg's Arch. Pharmacol. 287, R 54 (1975)Google Scholar
  9. Johns, E. J., Singer, R. B.: Effects of adrenaline, noradrenaline, isoprenaline and salbutamol on the production and release of renin by isolated renal cortical cells of the cat. Brit. J. Pharmacol. 53, 67–73 (1975)Google Scholar
  10. Meyer, D. K.: Effect of vasoconstrictors on the isoprenaline-induced renin release. Naunyn-Schmiedeberg's Arch. Pharmacol. 287, R 53 (1975)Google Scholar
  11. Meyer, D. K., Abele, M., Hertting, G.: Influence of serotonin on water intake and the renin-angiotensin system in the rat. Arch. int. Pharmacodyn. 212, 130–140 (1974)Google Scholar
  12. Nolly, H. L., Reid, J. A., Ganong, W. F.: Effect of theophylline and adrenergic blocking drugs on the renin response to norepinephrine in vitro. Circulat. Res. 35, 575–579 (1974)Google Scholar
  13. Peskar, B., Meyer, D. K., Tauchmann, U., Hertting, G.: Influence of isoproterenol, hydralazine and phentolamine on the renin activity of plasma and renal cortex of rats. Europ. J. Pharmacol. 9, 394–396 (1970)Google Scholar
  14. Vander, A. J.: Control of renin release. Physiol. Rev. 47, 359–382 (1967)Google Scholar
  15. Vandongen, R., Peart, W. S., Boyd, G. W.: Adrenergic stimulation of renin secretion in the isolated perfused rat kidney. Circulat. Res. 32, 290–296 (1973)Google Scholar
  16. Vandogen, R., Peart, W. S., Boyd, G. W.: Effect of angiotensin II and its nonpressor derivatives on renin secretion. Amer. J. Physiol. 226, 277–282 (1974)Google Scholar

Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • D. K. Meyer
    • 1
    • 2
  • G. Hertting
    • 1
    • 2
  • Ch. Mittermayer
    • 1
    • 2
  1. 1.Pathologisches Institut der Universität FreiburgFreiburgGermany
  2. 2.Pharmakologisches Institut der Universität Freiburg i. Br.Germany

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