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Protective effect of saikosaponin-d isolated from Bupleurum falcatum L. on CCl4-induced liver injury in the rat

Naunyn-Schmiedeberg's Archives of Pharmacology volume 320, pages 266–271 (1982)Cite this article

Summary

The effects of saikosaponin-d extracted from the roots of Bupleurum falcatum L. on carbon tetrachloride-induced hepatic injury were studied in rats. Pretreatment with saikosaponin-d produced a remarkable inhibitory action on acute hepatic injury by CCl4. A significant inhibition of lipid peroxidation induced by an acute dose of CCl4 in the liver of rats pre-treated with saikosaponin-d was also noted.

Continuous injection of CCl4 caused liver cirrhosis in rats but the severity of cirrhosis was reduced in rats treated simultaneously with CCl4 and saikosaponin-d.

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Authors and Affiliations

  1. The Research Institute of Oriental Medicine Kinki University, Nishiyama, Sayama-cho Minamikawachi-gun, 589, Osaka

    Hiroko Abe, Machiko Sakaguchi & Shigeru Arichi

  2. Department of Pathology, Kanazawa Medical University, Uchinada, Kahoku-gun, 920-02, Ishikawa, Japan

    Shizuo Odashima

Authors
  1. Hiroko Abe
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  2. Machiko Sakaguchi
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  3. Shizuo Odashima
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  4. Shigeru Arichi
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Abe, H., Sakaguchi, M., Odashima, S. et al. Protective effect of saikosaponin-d isolated from Bupleurum falcatum L. on CCl4-induced liver injury in the rat. Naunyn-Schmiedeberg's Arch. Pharmacol. 320, 266–271 (1982). https://doi.org/10.1007/BF00510139

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  • DOI: https://doi.org/10.1007/BF00510139

Key words

  • Carbon tetrachloride
  • Lipid peroxide
  • Liver cirrhosis
  • Saikosaponin
  • Bupleurum falcatum L.