Skip to main content
SpringerLink
Log in

Lymphomatoid papulosis and Hodgkin's disease: Are they related?

  • Original Contributions
  • Published:
Archives of Dermatological Research Aims and scope Submit manuscript

Summary

Two different characteristic types of lymphomatoid papulosis (type A and type B) can be histologically distinguished, that represent the ends of a spectrum. In the present report, two patients are described. One patient with both lymphomatoid papulosis type A and type B lesions for more than 25 years developed Hodgkin's disease (nodular sclerosing type) in the para-aortic and para-iliac lymph nodes. Histologic examination of the skin lesions in the second patient, who had Hodgkin's disease (nodular sclerosing type) in many supradiaphragmatic lymph nodes, showed the characteristic features of lymphomatoid papulosis type A. These findings, together with the results of recent immunohistochemical investigations showing many similarities between the large atypical cells in lymphomatoid papulosis type A lesions and Reed-Sternberg cells in Hodgkin's disease, support the view that lymphomatoid papulosis type A and Hodgkin's disease are closely related conditions. The results of recent studies indicate a close relationship between lymphomatoid papulosis type B and the early stages of mycosis fungoides. Accordingly, the possible relationship between lymphomatoid papulosis types A and B, mycosis fungoides, and Hodgkin's disease is discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Black MM (1982) Lymphomatiod papulosis and pityriasis lichenoides: Are they related? Br J Dermatol 106:717–721

    Google Scholar 

  • Breard J, Reinherz EL, Kung PC, Goldstein G, Schlossman SF (1980) A monoclonal antibody reactive with human peripheral blood monocytes. J Immunol 124:1943–1948

    Google Scholar 

  • Brehmer-Andersson I (1976) Mycosis fungoides and its relation to Sézary syndrome, lymphomatoid papulosis and primary cutaneous Hodgkin's disease. Acta Dermatol Venereol (Stockh) [Suppl] 56:75

    Google Scholar 

  • Chan WC, Griem ML, Grozea PN, Feel RJ, Variakojis D (1979) Mycosis fungoides and Hodgkin's disease occurring in the same patient. Cancer 44:1408–1413

    Google Scholar 

  • Colby TC, Burke JS, Hoppe RT (1981) Lymph node biopsy in mycosis fungoides. Cancer 47:351–359

    Google Scholar 

  • Degos R, Belaich S, Civatte J (1975) Maladie de Hodgkin ganglionnaire au course de l'évoluation d'un mycosis fungoides. Ann Dermatol Syph 100:499

    Google Scholar 

  • Donald J, Green JA, White M (1980) Mycosis fungoides associated with nodular sclerosing Hodgkin's disease. Cancer 46:2505–2508

    Google Scholar 

  • Dowd PM, Munro DD, Stansfeld AC (1981) Lymphomatoid papulosis and primary cutaneous Hodgkin's disease. J Royal Soc Med 74:68–71

    Google Scholar 

  • Drexhage HA, Lens JW, Cvetanov J, Kamperdijk EWA, Mullink R, Balfour BM (1980) Veiled cells resembling Langerhans cells. In: van Furth R (ed) Mononuclear phagocytes. Functional aspects, part 1. Nijhoff, The Hague, p 235

    Google Scholar 

  • Dvoretsky PH, Wood GS, Levy R, Wrnke RA (1982) T-lymphocyte subsets in follicular lymphomas compared with those in non-neoplastic lymph nodes and tonsils. Human Pathology 13:618–626

    Google Scholar 

  • Gordon RA, Lookingbill DP, Abt AB (1980) Skin infiltration in Hodgkin's disease. Arch Dermatol 116:1038–1040

    Google Scholar 

  • Harrist TJ, Bhan AK, Murphy GF, Sato S, Mihm MC (1982) Histiocytosis, vol X. In situ characterization of cutaneous lesion (abstract). J Invest Dermatol 78:354–355

    Google Scholar 

  • Hoefsmit ECM, Duyvestijn AM, Kamperdijk EWA (1982) Relation between Langerhans cells, veiled cells, and interdigitating cells. Immunbiol 161:255–265

    Google Scholar 

  • Hovelborg C (1932) Die isolierte Lymphogranulomatose der Haut. Arch Dermatol Syph 166:135–151

    Google Scholar 

  • Jimbow K, Chiba M, Horikoshi T (1982) Electron microscope identification of Langerhans cells in the dermal infiltrates of mycosis fungoides. J Invest Dermatol 78:102–107

    Google Scholar 

  • Kadin ME (1980) A reappraisal of the Reed-Sternberg cell. Blood Cells 6:525–532

    Google Scholar 

  • Kaiserling E (1978) Ultrastructure of non-Hodgkin's lymphomas. In: Lennert K (ed) Malignant lymphomas other than Hodgkin's disease. disease. Springer, Berlin Heidelberg New York, p 172

    Google Scholar 

  • Le Bien TW, Kersey JH (1980) A monoclonal antibody (TA-1) reactive with human T-lymphocytes and monocytes. J Immunol 125:2208–2214

    Google Scholar 

  • Mackie RM (1981) Initial event in mycosis fungoides of the skin in viral infection of epidermal Langerhans cells. Lancet 2:283–285

    Google Scholar 

  • Motoi M, Stein H, Lennert K (1980) Demonstration of lyzozyme, alpha1-antitrypsin, alpha1-antichymotrypsin, albumin and transferrin with the immunoperoxidase method in lymph node cells. Virchows Arch [Cell Pathol] 35:73

    Google Scholar 

  • Murphy GF, Bhan AK, Sato S, Mihm MC Jr, Harrist TJ (1981) A new immunologic marker for human Langerhans cells. New Eng J Med 304:791–792

    Google Scholar 

  • Oseroff AR, Wood GS, Wood C, Deneau DG (1982) Pleomorphic Langerhans cell tumor. In: Case presentation. XVI Congressus Internationalis Dermatologiae, Tokyo. University of Tokyo Press, p 957

    Google Scholar 

  • Poppema S (1979) Immunohistology of Hodgkin's disease. Thesis, Groningen

  • Poppema S, Bhan AK, Reinherz EL, Posner MR, Schlossman SF (1982) In situ immunologic characterization of cellular constituents in lymph nodes and spleens involved by Hodgkin's disease. Blood 59:226–232

    Google Scholar 

  • Powell SM, Ryan TJ, Dawber RPR, Bowers RI (1980) Mycosis fungoides and Hodgkin's disease. Br J Dermatol 103:69

    Google Scholar 

  • Rappaport H, Thomas LB (1974) Mycosis fungoides: The pathology of extracutaneous involvement. Cancer 34:1198–1229

    Google Scholar 

  • Rowden G, Lewis MG (1976) Langerhans cells: Involvement in the pathogenesis of mycosis fungoides. Br J Dermatol 95:665–672

    Google Scholar 

  • Rowden G, Philips TM, Lewis MG, Williamson RD (1979) Target role of Langerhans cells in mycosis fungoides. Transmission and immunoelectron microscopic studies. J Cutan Pathol 6:364–382

    Google Scholar 

  • Rubins J (1978) Cutaneous Hodgkin's disease. Indolent course and control with chemotherapy. Cancer 42:1219–1221

    Google Scholar 

  • Scheen SR, Doyle JA, Winkelman RK (1981) Lymphoma-associated papulosis: Lymphomatoid papulosis associated with lymphoma. J Am Acad Dermatol 4:451–457

    Google Scholar 

  • Scheffer E, Meijer CJLM, Van Vloten WA (1980) Dermatopathic lymphadenopathy and lymph node involvement in mycosis fungoides. Cancer 45:137–148

    Google Scholar 

  • Smith JL, Butler JJ (1980) Skin involvement in Hodgkin's disease. Cancer 45:354–361

    Google Scholar 

  • Stein H, Gerdes J, Kirchner H, Diehl V, Schaadt M, Bonk A, Steffen T (1981) Immunohistological analysis of Hodgkin's and Sternberg-Reed cells: Detection of a new antigen and evidence for selective IgG uptake in the absence of B-cell, T-cell and histiocytic markers. J Cancer Res Clin Oncol 101:125–134

    Google Scholar 

  • Szur L, Harrison CV, Levenne GM, Samman PD (1970) Primary cutaneous Hodgkin's disease. Lancet 1:1016–1020

    Google Scholar 

  • Tan RSH, Butterworth CM, McLaughlen H, Malka H, Samman PD (1974) Mycosis fungoides — a disease of antigen persistence. Br J Dermatol 91:607–616

    Google Scholar 

  • Thomas JA, Janossy G, Graham-Brown RAC, Kung PC, Goldstein G (1982) The relationship between T-lymphocyte subsets and Ialike antigen positive non-lymphoid cells in early stages of cutaneous T-cell lymphoma. J Invest Dermatol 78:169–176

    Google Scholar 

  • Ugolini V, Nunez G, Smith GR, Stastny P, Capra DJ (1980) Initial characterization of monoclonal antibodies against human monocytes. Proc Natl Acad Sci USA 77:6764–6768

    Google Scholar 

  • Van Leeuwen AWFM, Meijer CJLM, Van Vloten WA, Scheffer E, De Man JCH (1976) Further evidence for the T-cell nature of the atypical mononuclear cells in mycosis fungoides. Virchows Arch [Cell Pathol] 21:179–187

    Google Scholar 

  • Van Der Meiren L (1948) Three cases of Hodgkin's disease with predominantly cutaneous localization. Br J Dermatol 60:181–184

    Google Scholar 

  • Van Der Putte SCJ, Toonstra J, Go DMDS, Van Unnik JAM (1982) Mycosis fungoides. Demonstration of a variant simulating Hodgkin's disease. Virchows Arch [Cell Pathol] 40:231–247

    Google Scholar 

  • Van Der Valk P, Te Velde J, Jansen J, Ruiter DJ, Spaander PJ, Cornelisse CJ, Meijer CJLM (1981) Malignant lymphoma of true histiocytic origin: Histiocytic sarcoma. A morphological, ultrastructural, immunological, cytochemical and clinical study of 10 cases. Virchows Arch [Pathol Anat] 391:249–265

    Google Scholar 

  • Van Der Valk P, Van Den Besselaar-Dingjan G, Daha M, Meijer CJLM (1982) Analysis of large-cell lymphomas using monoclonal and heterologous antibodies. J Clin Pathol (in press)

  • Weinman VF, Ackerman AB (1981) Lymphomatoid papulosis. A critical review and new findings. Am J Dermatopathol 3:129–163

    Google Scholar 

  • Willemze R, Mejier CJLM, Van Vloten WA, Scheffer E (1982a) The clinical and histological spectrum of lymphomatoid papulosis. Br J Dermatol 107:131–144

    Google Scholar 

  • Willemze R, Ruiter DJ, Van Vloten WA, Meijer CJLM (1982b) “Reticulum cell sarcomas” (large cell lymphomas) presenting in the skin. High frequency of true histiocytic lymphoma (histiocytic sarcoma). Cancer 50:1367–1379

    Google Scholar 

  • Willemze R, Scheffer E, Ruiter DJ, Van Vloten WA, Meijer CJLM (1983a) Immunological, cytochemical and ultrastructural studies in lymphomatoid papulosis. Br J Dermatol 108:381–394

    Google Scholar 

  • Willemze R, De Graff-Reitsma CB, Cnossen J, Van Vloten WA, Meijer CJLM (1983b) Characterization of T-cell subpopulations in skin and peripheral blood of patients with cutaneous T-cell lymphomas and benign inflammatory dermatoses. J Invest Dermatol 80:60–66

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, University Hospital, Rijnsburgerweg 10, NL-2333 AA, Leiden, The Netherlands

    E. Scheffer & C. J. L. M. Meijer

  2. Department of Pathology, University Hospital, Rijnsburgerweg 10, NL-2333 AA, Leiden, The Netherlands

    R. Willemze & W. A. Van Vloten

  3. Department of Pathology, SSDZ, Delft, The Netherlands

    C. J. L. M. Meijer

Authors
  1. R. Willemze
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Scheffer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W. A. Van Vloten
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. J. L. M. Meijer
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported by a grant (LUKC 82-09) from the Koningin Wilhelmina Fonds

Rights and permissions

Reprints and permissions

About this article

Cite this article

Willemze, R., Scheffer, E., Van Vloten, W.A. et al. Lymphomatoid papulosis and Hodgkin's disease: Are they related?. Arch Dermatol Res 275, 159–167 (1983). https://doi.org/10.1007/BF00510047

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00510047

Key words

Search

Navigation