Synthesis of ω-substituted 5-alkylorotic acids
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The lactone of 5 -β -hydroxyethylorotic acid, the thiolactone of 5-(δ-mercaptoethyl)orotic acid, and 5-(δ-benzamidobutyl)orotic acid were synthesized from substituted 5-carb-ethoxymethylenehydantoins obtained by the condensation of urea with α-ethoxalyl derivatives of γ-butyrolactone, γ-thiobutyrolactone, and ethyl ε-benzamidocaproate. The lactam of 5-(β-aminoethyl)orotic acid was synthesized by the ammonolysis of the lactone of 5 -(β-hydroxyethyl)orotic acid. The acid hydrolysis of 5-(δ-benzamidobutyl)orotic acid gave 5-(δ-aminobutyl)orotic acid.