Chemistry of Heterocyclic Compounds

, Volume 7, Issue 9, pp 1202–1203 | Cite as

Synthesis of ω-substituted 5-alkylorotic acids

  • A. Ya. Berlin
  • I. A. Korbukh


The lactone of 5 -β -hydroxyethylorotic acid, the thiolactone of 5-(δ-mercaptoethyl)orotic acid, and 5-(δ-benzamidobutyl)orotic acid were synthesized from substituted 5-carb-ethoxymethylenehydantoins obtained by the condensation of urea with α-ethoxalyl derivatives of γ-butyrolactone, γ-thiobutyrolactone, and ethyl ε-benzamidocaproate. The lactam of 5-(β-aminoethyl)orotic acid was synthesized by the ammonolysis of the lactone of 5 -(β-hydroxyethyl)orotic acid. The acid hydrolysis of 5-(δ-benzamidobutyl)orotic acid gave 5-(δ-aminobutyl)orotic acid.


Hydrolysis Ethyl Urea Organic Chemistry Lactone 
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Literature cited

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    A. Ya. Berlin and I. A. Korbukh, Khim. Geterotsikl. Soedin., 397 (1971).Google Scholar
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Copyright information

© Consultants Bureau 1974

Authors and Affiliations

  • A. Ya. Berlin
    • 1
  • I. A. Korbukh
    • 1
  1. 1.Institute of Experimental and Clinical OncologyAcademy of Medical Sciences of the USSRMoscow

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