Abstract
The corresponding N1-(2-furoylmethyl) and N1-(5-nitro-2-furoylmethyl) derivatives of uracil and its 5-substituted derivatives were obtained by the reaction of 2-bromo- and 5-nitro-2-bromoacetylfurans with uracil, 5-fluorouracil, and thymine. The structures of these compounds as N1-substituted uracils were proved by a study of the UV spectra at various pH values. The computational method of expanding the UV spectra into individual bands was used.
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C. Heidelberger, Progress in Nucleic Acid Research and Molecular Biology, Vol. 4 (1965), p. 1.
S. A. Giller, R. A. Zhuk, and M. Yu. Lidak, Dokl. Akad. Nauk SSSR, 176, 332 (1967).
A. F. Blyuger, Nitrofurans and Their Use in Medicine [in Russian], Akad. Nauk Latv. SSR, Riga (1958).
L. N. Alekseeva, Antibacterial Preparations — 5-Nitrofuran Derivatives [in Russian], Riga (1963).
L. V. Kruzmetra, Nitrofuran Preparations in Combatting Staphylococcus Infection [in Russian], Riga (1964).
E. Wittenburg, Z. Chem., 4, 303 (1964).
S. A. Giller, M. Yu. Lidak, R. A. Zhuk, A. A. Berzinya, K. Ya. Pets, I. N. Getsova, and É. I. Bruk, Khim. Geterotsikl. Soedin., 375 (1969).
D. Shugar and J. J. Fox, Biochim. Biophys. Acta, 9, 199 (1952).
Ya. Éidus, A. Ékmane, K. Venter, and S. Giller, Atlas of Electronic Spectra of 5-Nitrofuran Compounds [in Russian], Riga (1968), p. 18.
I. Pitha and R. N. Jones, Can. J. Chem., 44, 3031 (1966).
D. J. Wild, Methods for Seeking Extrema [Russian translation], Nauka, Moscow (1967).
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1268–1270, September, 1971.
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Giller, S.A., Perkone, A.Y., Getsova, I.N. et al. N1-(2-furoylmethyl) and N1-(5-nitro-2- furoylmethyl) derivatives of uracil and its 5-substituted derivatives. Chem Heterocycl Compd 7, 1191–1193 (1971). https://doi.org/10.1007/BF00510035
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DOI: https://doi.org/10.1007/BF00510035