Chemistry of Heterocyclic Compounds

, Volume 7, Issue 9, pp 1173–1176 | Cite as

Investigations in the imidazole series

LXV. Synthesis of 2-aminoimidazole derivatives from 2-haloimidazoles
  • B. A. Priimenko
  • P. M. Kochergin


The reaction of 1-alkyl(hydroxyalkyl)-2-bromo-4,5-diphenylimidazoles with ammonia and primary and secondary amines was studied, and a new synthesis of 2-aminoimidazole derivatives was realized on the basis of 2-haloimidazoles. The starting compounds were obtained by the bromination of 1-alkyl(hydroxyalkyl)-4,5-diphenylimidazoles with bromine or by alkylation of 2-bromo-4,5-diphenylimidazole with alkyl halides, β -halo alcohols, and olefin oxides.


Oxide Alcohol Ammonia Organic Chemistry Imidazole 
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Copyright information

© Consultants Bureau 1974

Authors and Affiliations

  • B. A. Priimenko
    • 1
    • 2
  • P. M. Kochergin
    • 1
    • 2
  1. 1.Zaporozhe State Medical InstituteUSSR
  2. 2.S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical ChemistryMoscow

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