Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 295, Issue 1, pp 41–44 | Cite as

Evidence for stimulation of 5-HT receptors in canine saphenous arteries by ergotamine

  • Else Müller-Schweinitzer


Changes in tension of spiral strips from dog saphenous arteries were monitored isometrically. Dose-response curves for noradrenaline, 5-HT and ergotamine were established without and after a 30 min incubation with phentolamine or pizotifen. Phentolamine was about 15 times more potent in antagonizing responses to noradrenaline (pA2 value=7.4) than those to 5-HT (pA2 value=6.2) but it was nearly equipotent in antagonizing responses to ergotamine (pA2 value=6.5) and those to 5-HT. Pizotifen was about 500 times less potent in antagonizing noradrenaline effects than 5-HT but again nearly equipotent when tested against ergotamine and 5-HT.

It is suggested that in canine saphenous arteries the stimulant activity of ergotamine is mediated mainly through 5-HT receptors.

Key words

Arteries Ergotamine 5-HT Receptors Pizotifen Phentolamine 


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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • Else Müller-Schweinitzer
    • 1
  1. 1.Medizinisch-Biologische ForschungSandoz AGBaselSwitzerland

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