Archives of Dermatological Research

, Volume 272, Issue 3–4, pp 387–391 | Cite as

Allergic contact gingivostomatitis due to gold

  • Allan K. Izumi


The sixth case of an allergic contact gingivostomatitis to gold crowns previously misdiagnosed as erosive lichen planus is reported. Patch tests to gold chloride (0.5%) and 0.05 cm3 intradermal gold sodium thiomalate (Myochrysine 50 mg/cm3) were positive at 48–72 h.

Histopathology of the allergic contact gingivitis revealed a pseudolymphomatous inflammatory dermal reaction with a dense lymphohistiocytic and plasma cell infiltrate. Removal of the gold crowns resulted in a gradual resolution of the gingivostomatitis in 4–6 months, and the patient has remained free of clinical disease for over 3 years. A review of the reported cases of allergic gingivostomatitis to gold crowns revealed that each patient clinically presented with an erosive and ulcerative inflammatory response was usually associated with a clinical history of gold jewelry intolerance.

Key words

Gold allergy Allergic contact gingivostomatitis Schlüsselwörter Goldallergie kontaktallergische Gingivostomatitis 


Es wird der bisher sechste Fall einer kontaktallergischen Gingivostomatitis auf Goldkronen berichtet. Die Erkrankung war als erosiver Lichen ruber mucosae fehlgedeutet worden. Läppchentestungen mit Goldchlorid (0,5%) und Intrakutantestungen mit 0,5 ml Gold-Natriumthiomalat (Myochrysin, 50 mg/ml) zeigten nach 48 und 72 h positive Reaktionen.

Histopathologisch fand sich eine pseudolymphomatoide Reaktion mit einmen dichten dermalen Infiltrat aus Lymphozyten und Plasmazellen. Nach der Entfernung der Kronen bildete sich die Gingivostomatitis in Verlauf von 4–6 Monaten zunehmend zurück. Über 3 Jahre war der Patient seither klinisch erscheinungsfrei geblieben. Eine Durchsicht der Literaturmitteilungen über durch Gold verursachte allergische Gingivostomatiden ergab, daß sämtliche Patienten erosive, ulzerierende Reaktion zeigten und gewöhnlich eine Unverträglichkeit von Goldschmuck vorher bekannt war.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Gibbons RB (1979) Complications of chrysotherapy — A review of recent studies. Arch Int Med 139:343–346Google Scholar
  2. 2.
    Penneys NC, Ackerman AB, Gottlieb NC (1974) Gold dermatitis. A clinical and histopathological study. Arch Dermatol 109:372–376Google Scholar
  3. 3.
    Kligman AM (1966) The identification of contact allergens by human assay. III. Maximization test: A procedure for screening and rating contact sensitizers. J Invest Dermatol 47:393–409Google Scholar
  4. 4.
    Shelley WB, Epstein E (1963) Contact-sensitivity to gold as a chronic papular eruption. Arch Dermatol 87:388–391Google Scholar
  5. 5.
    Petros H, MacMillan AL (1973) Allergic contact sensitivity to gold with unusual features. Br J Dermatol 88:505–508Google Scholar
  6. 6.
    Young E (1974) Contact hypersensitivity to metallic gold. Dermatologica 149:294–298Google Scholar
  7. 7.
    Bowyer A (1967) Epidermal reactions and prolonged dermal reactions to patch testing with gold salts. Acta Derm Venereol (Stockh) 47:9–14Google Scholar
  8. 8.
    Gaul EL (1954) Incidence of sensitivity to chromium nickel, gold, silver and copper compared to reactions to their aqueous salts including cobalt sulfate. Ann Allergy 12:429–444Google Scholar
  9. 9.
    Fox JM, Kennedy R, Rostenberg A Jr (1961) Eczematous contact-sensitivity to gold. Arch Dermatol 83:110–113Google Scholar
  10. 10.
    Comaish S (1969) A case of contact hypersensitivity to metallic gold. Arch Dermatol 99:720–723Google Scholar
  11. 11.
    Cowan MA (1960) Contact dermatitis due to gold. Br J Dermatol 72:348–349Google Scholar
  12. 12.
    Forster WH, Dickey RF (1949) A case of sensitivity to gold-ball orbital implant. Eczematous contact-type dermatitis due to 14-karat gold. Am J Ophthalmol 32:659–662Google Scholar
  13. 13.
    Elgart ML, Higdon RS (1971) Allergic contact dermatitis to gold. Arch Dermatol 103:649–653Google Scholar
  14. 14.
    Schöpf E, Wex O, Schulz KH (1970) Allergische Kontaktstomatitis mit spezifischer Lymphocytenstimulation durch Gold. Hautarzt 21:422–424Google Scholar
  15. 15.
    Klaschka F (1975) Contact dermatitis to gold. Contact Dermatitis 1:264–265Google Scholar
  16. 16.
    Fregert S (1979) Allergic contact stomatitis from gold dentures. Contact Dermatitis 5:63–64Google Scholar
  17. 17.
    Cronin E (1980) Contact dermatitis. Churchill Livingstone, Edinburgh London New York, pp 334–335Google Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Allan K. Izumi
    • 1
  1. 1.Division of DermatologyUniversity of Hawaii John A. Burns, School of MedicineHonoluluUSA

Personalised recommendations