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Reduction of the erythema response to ultraviolet light by nonsteroidal antiinflammatory agents


The effect of three nonsteroidal antiinflammatory agents (NSAIA) on ultraviolet B (UV-B)-induced erythema was studied in normal human volunteers. Aspirin, indomethacin, and ibuprofen were administered orally 2 h before exposure to UV-B from fluorescent sunlamps and at 4-h intervals for a total of four doses. The minimal dose of light to produce erythema (MED) was determined for each subject with and without drugs. There was a 240% increase in the mean MED when the NSAIA were given. NSAIA, given orally, can increase the threshold for UV-B-induced erythema when administered near the time of irradiation.


Der Effekt von drei nicht-steroidalen antientzündlichen Substanzen (NSAIA) auf das durch Ultraviolettlicht B (UV-B) erzeugte Erythem wurde an gesunden Freiwilligen untersucht. Aspirin, Indomethazin und Ibuprofen wurden 2 h vor der UV-B-Exposition mit Fluoreszenzlampen und danach in Intervallen von 4 h insgesamt viermal oral verabreicht. Die minimale erythemerzeugende Lictosis (MED) wurde an allen Probanden mit und ohne Medikation bestimmt. Bei Verabreichung von NSAIA fand sich ein durchschnittlicher Anstieg der MED um 240%. Oral verabreichte NSAIA können die Erythemschwellendosis für UV-B erhöhen, wenn sie in kurzem zeitlichen Abstand zur Bestrahlung verabfolgt werden.

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Correspondence to Edward K. Edwards Jr..

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Edwards, E.K., Horwitz, S.N. & Frost, P. Reduction of the erythema response to ultraviolet light by nonsteroidal antiinflammatory agents. Arch Dermatol Res 272, 263–267 (1982).

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Key words

  • Nonsteroidal antiinflammatory agents
  • UV-B erythema
  • Minimal erythema dose


  • Nicht-steroidale antientzündliche Substanzen
  • UV-B-Erythem
  • Minimale Erythemdosis