Summary
B 16 mouse melanoma maintained on nonagouti a/a mice (C 57 Bl 6j subline) was transplanted to ‘Yellow’ Ay/a mutants. B 16 melanoma has now been maintained for 1 year on the ‘Yellow’ strain. A microscopic and ultrastructural study of transplanted tumors is described. Several enzymatic activities including tyrosinases are investigated. A marked depigmentation of the B 16 melanoma is noted after its transplantation to the ‘Yellow’ strain, and melanogenic characteristics of the tumor are modified.
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This work was supported by I.N.S.E.R.M. Grant ATP 67.78.99
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Voulot, C., Ortonne, J.P., Benedetto, J.P. et al. Amelanotic changes in B 16 melanoma after transplantation to ‘Yellow’ Ay/a mice. Arch Dermatol Res 273, 51–60 (1982). https://doi.org/10.1007/BF00509027
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DOI: https://doi.org/10.1007/BF00509027