Summary
A 77-year-old woman developed a diffuse nodular eruption with histologic, ultrastructural, and biologic evidence of cutaneous T-cell lymphoma (CTCL) limited to the skin. She was treated with a new aromatic retinoid Ro 10-9359 (1 mg/kg/day). After 34 days, the lesions flattened completely and the mononuclear cell infiltrate decreased significantly. No clinical recurrences occured after a 4-month survey. Discontinuation of the aromatic retinoid led to a relapse with identical clinical and histologic features.
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References
Bollag W (1974) Therapeutic effects of an aromatic retinoic acid analog on chemically induced skin papillomas and carcinomas of mice. Eur J Cancer 10:731–737
Bollag W, Ott F (1975) Vitamin A acid in benign and malignant epithelial tumors of the skin. Acta Derm Venereol [Suppl] (Stockh) 74:163–166
Edelson RL (1980) Round cells of the epidermis. Clues from studies on neoplastic lymphocytes of cutaneous T-cell lymphoma. J Invest Dermatol 75:95–102
Fredriksson T, Pettersson U (1978) Severe psoriasis-oral therapy with a new retinoid. Dermatologica 157:238–242
Fredriksson T (1978) Oral treatment of psoriasis and pustulosis palmo-plantaris with Ro 10-9359. Dermatologica [Suppl 1] 157:13–18
Fuks ZY, Bagshaw MA, Farber EM (1973) Prognostic signs and the management of the mycosis fungoides. Cancer 32:1385–1395
Gilchrest BA, Parrish JA, Tananbaum L, Haynes HA, Fitzpatrick TB (1976) Oral methoxsalen photochemotherapy of mycosis fungoides. Cancer 38:683–689
Guilhou JJ, Malbos S, Meynadier J (1978) Traitement oral des psoriasis graves par un nouveau retinoid aromatique (Ro 10-9359). Ann Dermatol Venereol 105:813–818
Lassus A (1980) Systemic treatment of psoriasis with an oral retinoic acid derivative (Ro 10-9359). Br J Dermatol 102:195–202
Lauharanta J (1980) Retinoids in the treatment and prevention of dermatoses and epithelial neoplasias. Ann Clin Res 12:123–130
Mayer H, Bollag W, Hanni R, Ruegg R (1978) Retinoids, a new class of compounds with prophylactic and therapeutic activities in oncology and dermatology. Experientia 34:1105–1119
Orfanos CE, Kurka M, Strunk V (1978) Oral treatment of keratosis follicularis with a new aromatic retinoid. Arch Dermatol 114:1211–1214
Orfanos CE (1980) Oral retinoids-present status. Br J Dermatol 103:473–481
Ryssel H, Brunner K, Bollag W (1971) Die perorale Anwendung von Vitamin-A-Säure bei Leukoplakien, Hyperkeratosen und Plattenepithelkarzinomen: Ergebnisse und Verträglichkeit. Schweiz Med Wochenschr 101:1027–1030
Schnitzler L, Schubert B, Verret JL (1980) Essai der prévention des épitheliomas cutanés par le rétinoïde aromatique. Ann Derm Venereol (Paris) 107:657–663
Schuppli R (1978) The efficacy of a new retinoid (Ro 10-9359) in lichen planus. Dermatologica [Suppl 1] 157:60–63
Sporn MB, Newton DL (1979) Chemoprevention of cancer with retinoids. Fed Proc 38:2528–2534
Thune P, Mork NJ (1980) A case of centrolobular toxic necrosis of the liver due to aromatic retinoid-Tigason (Ro 10-9359). Dermatologica 160:405–408
Van Scott EJ, Kalmanson JD (1973) Complete remissions of mycosis fungoides lymphoma induced by topical nitrogen mustard (HN 2). Control of delayed hypersensitivity of HN 2 by desensitization and by induction of specific immunologic tolerance. Cancer 32:18–29
Weeks C, Slaga T, Hennings H, Gelason G, Bracken W (1979) Inhibition of phorbol ester-induced tumour promotion in mice by vitamin A analog and anti-inflammatory steroid. J Natl Cancer Inst 63:401–406
Elias PM, Williams ML (1981) Retinoids, cancer, and the skin. Arch Dermatol. 117:160–180
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Claudy, A.L., Delomier, Y. & Hermier, C. Treatment of cutaneous T-cell lymphoma with a new aromatic retinoid (Ro 10-9359). Arch Dermatol Res 273, 37–42 (1982). https://doi.org/10.1007/BF00509025
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DOI: https://doi.org/10.1007/BF00509025