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Effects of some inhibitors of phosphodiesterase on neuromuscular transmission

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Summary

Phosphodiesterase inhibitors antagonized the d-tubocurarine-induced paralysis of the indirectly stimulated rat phrenic nerve-diaphragm preparation. Ro 7-2956, papaverine and hydrochlorothiazide were active in 1/5 to 1/100 the concentrations of theophylline. This antagonism may be caused by the intracellular accumulation of c-AMP, which in turn may facilitate the release of acetylcholine from motor nerve endings.

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Authors and Affiliations

  1. Department of Pharmacology, University of Oulu, Oulu, Finland

    H. Vapaatalo & P. Anttila

  2. Department of Pharmacology, University of Helsinki, Hensinki, Finland

    H. Vapaatalo & P. Anttila

Authors
  1. H. Vapaatalo
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  2. P. Anttila
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Vapaatalo, H., Anttila, P. Effects of some inhibitors of phosphodiesterase on neuromuscular transmission. Naunyn-Schmiedeberg's Arch. Pharmacol. 275, 227–232 (1972). https://doi.org/10.1007/BF00508910

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  • DOI: https://doi.org/10.1007/BF00508910

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