The termination of action of exogenous noradrenaline in the isolated cat spleen tissue

  • F. Brandão
  • S. Guimarães


The influence of cocaine, iproniazid and tropolone on the inactivation of exogenous noradrenaline was studied in cat spleen strips. The results show that, in this preparation, neuronal uptake represents the most important pathway of inactivation, oxidative deamination and O-methylation being of lesser importance. The influence of cocaine on the sensitivity to noradrenaline and on the inactivation of noradrenaline in this preparation correlates well with that observed in other preparations, showing that there is a causal relationship between rate of inactivation and supersensitivity, though the additional influence of other factors cannot be excluded.

Key words

Cat Splenic Strips Inactivation of Noradrenaline Cocaine Supersensitivity to Noradrenaline 


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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • F. Brandão
    • 1
  • S. Guimarães
    • 1
  1. 1.Department of PharmacologyMedical FacultyPortoPortugal

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