The termination of action of exogenous noradrenaline in the isolated cat spleen tissue
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The influence of cocaine, iproniazid and tropolone on the inactivation of exogenous noradrenaline was studied in cat spleen strips. The results show that, in this preparation, neuronal uptake represents the most important pathway of inactivation, oxidative deamination and O-methylation being of lesser importance. The influence of cocaine on the sensitivity to noradrenaline and on the inactivation of noradrenaline in this preparation correlates well with that observed in other preparations, showing that there is a causal relationship between rate of inactivation and supersensitivity, though the additional influence of other factors cannot be excluded.
Key wordsCat Splenic Strips Inactivation of Noradrenaline Cocaine Supersensitivity to Noradrenaline
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- Furchgott, R. F., Sanchez Garcia, P.: Effects of inhibition of monoamine oxidase on the actions and interactions of norepinephrine, tyramine and other drugs on guinea-pig left atrium. J. Pharmacol. exp. Ther. 163, 98–122 (1968).Google Scholar
- Guimarães, S.: The slopes of cumulative and non-cumulative dose-response curves for noradrenaline and isoprenaline. Europ. J. Pharmacol. 17, 44–49 (1972).Google Scholar
- Guimarães, S., Osswald, W., Cardoso, W., Branco, D.: The effects of cocaine and denervation on the sensitivity to noradrenaline, its uptake and termination of its action in isolated venous tissue. Naunyn-Schmiedebergs Arch. Pharmak. 271, 262–273 (1971).Google Scholar
- Iversen, L. L.: The uptake of catechol amines at high perfusion concentrations in the rat isolated heart: a novel catechol amine uptake process. Brit. J. Pharmacol. 25, 18–33 (1965).Google Scholar
- Kalsner, S., Nickerson, M.: A method for the study of mechanisms of drug disposition in smooth muscle. Canad. J. Physiol. 46, 719–730 (1968).Google Scholar
- Kalsner, S., Nickerson, M.: Disposition of norepinephrine and epinephrine in vascular tissue, determined by the technique of oil immersion. J. Pharmacol. exp. Ther. 165, 152–165 (1969a).Google Scholar
- Kalsner, S., Nickerson, M.: Mechanism of cocaine potentiation of responses to amines. Brit. J. Pharmacol. 35, 428–439 (1969b).Google Scholar
- Osswald, W., Guimarães, S., Coimbra, A.: The termination of action of catecholamines in the isolated venous tissue of the dog. Naunyn-Schmiedebergs Arch. Pharmak. 269, 15–31 (1971)Google Scholar