Skip to main content
SpringerLink
Log in

Molekülgerüst und Arzneimittelwirkung Beispiel: Sexualhormone

  • Published:
Naturwissenschaften Aims and scope Submit manuscript

Abstract

In sexual-hormone activity differences arise when only a minimum change in the structure of a known molecule is made. Even the physiological hormones have similar structures but extremely different properties. Small variations of the steroid molecule lead to orally active progestogens and estrogens. The discovery of orally active androgens and the development of anabolic agents and antiandrogens proceeds also by very small changes of known structures. Out of a million possible variations of the steroid molecule, the synthesis of approximately 80 000 structures has been realized.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Bibliography

  1. Neumann, F.: Sexualmedizin 5, 482 (1976)

    Google Scholar 

  2. Neumann, F., Wiechert, R.: Deutsches Museum — Abhandlungen und Berichte 42, 1 (1974)

    Google Scholar 

  3. Neumann, F., in: Gauer, O.H., Kramer, K., Jung, R. (Hrsg.): Physiologie des Menschen, Bd. 19, S. 213. München-Wien- Baltimore: Urban & Schwarzenberg 1977

    Google Scholar 

  4. Neumann, F., Schenck, B., in: Forth, W., Henschler, D., Rummel, W. (Hrsg.): Allgemeine Pharmakologie und Toxikologie, S. 304. Mannheim-Wien-Zürich: Bibliographisches Institut 1975

    Google Scholar 

  5. Junkmann, K..: Z. Angew. Chem. 44, 162 (1931)

    Google Scholar 

  6. Inhoffen, H.H., Hohlweg, W.: Naturwissenschaften 26, 96 (1938)

    Google Scholar 

  7. Schoeller, W.: Letter to Dr. Schmidt (Febr. 2, 1955), Schering's Archives (unveröff.)

  8. Naftolin, F., Ryan, K.J., Petro, Z.: J. Endocr. 51, 795 (1971)

    Google Scholar 

  9. Nishino, Y., Neumann, F.: Acta Endocrinol., Suppl. 187, 1 (1974); Nishino, Y., et al.: Steroids (in press)

    Google Scholar 

Nicht im Text Zitierte Literatur

  1. Neumann, F., in: Kracht, J., von zur Mühlen, A., Scriba, P.C. (eds.): Endocrinology Guide — Federal Republic of Germany, p. 135. Gießen: Brühl'sche Universitäts-Druckerei 1976

    Google Scholar 

  2. Schoeller, W.: Med. Mitt. (Schering AG) 6, 3 (1934)

    Google Scholar 

  3. Schoeller, W.: Manuscript of a lecture 1935 or 1936, Schering's Archives (unpubl.)

  4. Schoeller, W., Schwenk, E., Hildebrandt, F.: Naturwissenschaften 21, 286 (1933)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department für Endokrinpharmakologie, Forschungslaboratorien der Schering AG, D-1000, Berlin

    F. Neumann

Authors
  1. F. Neumann
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Neumann, F. Molekülgerüst und Arzneimittelwirkung Beispiel: Sexualhormone. Naturwissenschaften 64, 410–416 (1977). https://doi.org/10.1007/BF00508692

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00508692

Search

Navigation