Chemistry of Heterocyclic Compounds

, Volume 20, Issue 6, pp 697–699 | Cite as

Alkylation of 5-substituted tetrazoles with mannich bases

  • V. G. Kitaeva
  • R. I. Ishmetova
  • N. I. Latosh
  • N. M. Voronina


Mixtures of N(1) and N(2) isomers are formed in the alkylation of 1H-5-R-tetrazoles with N-(2-hydroxy-3-methoxy-5-formylbenzyl)piperidine, whereas primarily one of two possible N(1) or N(2) isomers is formed in the case of alkylation with N-(3,5-di-methyl-4-hydroxybenzyl)piperidine, depending on substituent R.


Organic Chemistry Alkylation Tetrazoles Piperidine Mannich Base 
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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • V. G. Kitaeva
    • 1
  • R. I. Ishmetova
    • 1
  • N. I. Latosh
    • 1
  • N. M. Voronina
    • 1
  1. 1.Institute of Chemistry, Ural Science CenterAcademy of Sciences of the USSRSverdlovsk

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