Summary
-
1.
Tetanus toxin was injected into gastrocnemius muscles of cats and for 24 h its action on nerve condution of muscle afferents was investigated.
-
2.
During this period stimulus threshold and latency remained constant. No signs of fatigue were observed.
References
Acheson, G. H., Ratnoff, O. R., Schoenbach, E. B.: The localized action on the spinal cord of intramuscularly injected tetanus toxin. J. exp. Med. 75, 465–480 (1942)
Erdmann, G., Wiegand, H., Wellhöner, H. H.: Intraaxonal and extraaxonal transport of 125I-tetanus toxin in early local tetanus. Naunyn-Schmiedeberg's Arch. Pharmacol. 290, 357–373 (1975)
Hilbig, G., Erdmann, G., Räker, K. O., Wellhöner, H. H.: Local tetanus: uptake in vivo of (14C) glycine and amino acid concentrations as studied in spinal ganglia, spinal roots and spinal cord segments. Hoppe-Seylers Z. Physiol. Chem. 358, 250 (1977)
Kryzhanovsky, G. N., Ploniskii, L. A., Grafova, V. N., Polgar, A. A.: Routes of entrance of tetanus toxin into the central nervous system and some problems connected with the pathogenesis of experimental tetanus. Part II: Experiments on mice, guinea pigs, rabbits and cats. Bull. exp. Biol. Med. 52, 894–898 (1961)
Paar, G. H., Wellhöner, H. H.: The action of tetanus toxin on preganglionic sympathetic reflex discharges. Naunyn-Schmiedeberg's Arch. Pharmacol. 276, 437–445 (1973)
Sherrington, C. S.: On reciprocal innervation of antagonistic muscles. Eight Natl. Proc. roy. Soc. B 76, 269–297 (1905)
Stoeckel, K., Schwab, M., Thoenen, H.: Comparison between retrograde axonal transport of nerve growth factor and tetanus toxin in motor, sensory and adrenergic neurons. Brain Res. 99, 1–16 (1975)
Takano, K., Kano, M.: Gamma-bias of the muscle poisoned by tetanus toxin. Naunyn-Schmiedeberg's Arch. Pharmacol. 276, 413–420 (1973)
Wellhöner, H. H., Hensel, B., Seib, U. C.: Local tetanus in cats: Neuropharmacokinetics of 125I-tetanus toxin. Naunyn-Schmiedeberg's Arch. Pharmacol. 276, 375–386 (1973a)
Wellhöner, H. H., Seib, U. C., Hensel, B.: Local tetanus in cats: The influence of neuromuscular activity on spinal distribution of 125I-labelled tetanus toxin. Naunyn-Schmiedeberg's Arch. Pharmacol. 276, 387–394 (1973b)
Author information
Authors and Affiliations
Additional information
This work was supported by grant No. We 479/4 from the Deutsche Forschungsgemeinschaft
Rights and permissions
About this article
Cite this article
Wiegand, H., Hilbig, G. & Wellhöner, H.H. Early local tetanus: Does tetanus toxin change the stimulus evoked discharge in afferents from the injected muscle?. Naunyn-Schmiedeberg's Arch. Pharmacol. 298, 189–191 (1977). https://doi.org/10.1007/BF00508628
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00508628