, Volume 85, Issue 6, pp 441–452 | Cite as

Chromogranin A (CGA) in the gastro-entero-pancreatic (GEP) endocrine system

I. CGA in the mammalian endocrine pancreas
  • D. Grube
  • D. Aunis
  • F. Bader
  • Y. Cetin
  • A. Jörns
  • S. Yoshie


Chromogranin A (CGA), a protein at first detected in the adrenal medulla, has recently been found also in other organs, e.g. the endocrine pancreas. However, immunohistochemical findings concerning the cellular source of pancreatic CGA were controversial. Therefore, the endocrine pancreas of 10 mammalian species (man, tupaia, mole, cat, dog, pig, guinea pig, rabbit, rat) was investigated immunohistochemically for CGA-like immunoreactivities on serial semithin plastic sections using a high-titer polyclonal antiserum against bovine CGA. The results show that basically all pancreatic endocrine cell types are CGA-immunoreactive; however, every species has its own pattern of CGA-immunoreactive cell types. Other findings of the present studies indicate that the physiological function of CGA in pancreatic endocrine cells is related to the storage mechanisms of peptide hormones. Finally, a methodological approach is given to obtain not only qualitative but also semiquantitative data during immunohistochemical investigations.


Peptide Physiological Function Methodological Approach Mammalian Species Endocrine System 
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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • D. Grube
    • 1
  • D. Aunis
    • 2
  • F. Bader
    • 2
  • Y. Cetin
    • 1
  • A. Jörns
    • 1
  • S. Yoshie
    • 3
  1. 1.Abteilung Anatomie 1 der Medizinischen HochschuleHannoverGermany
  2. 2.Unité de NeurochimieINSERMStrasbourgFrance
  3. 3.Department of AnatomyNippon Dental UniversityNiigataJapan

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