Summary
The electrically evoked, calcium-dependent release of 3H-acetylcholine from slices of rat striatum was inhibited in a concentration-dependent manner by (+)-amphetamine (0.2–20 μM). This inhibitory effect of (+)-amphetamine was unaffected by depletion of the endogenous stores, of dopamine by pretreatment with rescrpine (5 mg/kg, 24h). However, the combined treatment of reserpine with α-methyl-p-tyrosine (300 mg/kg) or NSD 1015 (100 mg/kg) reduced significantly these inhibitory effects of (+)-amphetamine. Similar results were obtained after chronic 6-hydroxydopamine lesions of the corpus striatum. The inhibition of 3H-acetylcholine release by (+)-amphetamine in rats pretreated with reserpine was potentiated in the presence of 10 μM pargyline. These results support the view that the inhibitory effects of (+)-amphetamine on the electrically-evoked release of 3H-acetylcholine are mediated by dopamine released from a special pool of newly synthetized transmitter rather than through a direct action on an amphetamine recognition site or receptor.
This is a preview of subscription content, log in via an institution to check access.
References
Angrist BM, Gershon S (1970) The phenomenology of experimentally induced amphetamine psychosis. Preliminary observations. Biol Psychiat 2:95–107
Cantrill R, Arbilla S, Langer SZ (1983) Inhibition by (+)-amphetamine of the electrically-evoked release of 3H-acetylcholine from slices of the rat striatum: Involvement of dopamine receptors. Eur J Pharmacol 87:167–168
Feltz P, De Champlain J (1973) The postsynaptic effects of amphetamine on striatal dopamine-sensitive neurons. In: Usdin E, Snyder SH (eds) Frontiers in catecholamine research. Pergamon Press, London, pp 951–956
Hertting G, Zumstein A, Jackisch R, Hoffman I, Starke K (1980) Modulation by endogenous dopamine of the release of acetylcholine in the caudate nucleus of the rabbit. Naunyn-Schmiedeberg's Arch Pharmacol 315:111–117
Jönsson LE, Änggard E, Gunne LM (1971) Blockade of intravenous amphetamine euphoria in man. Clin Pharmacol Ther 12:889–896
Kamal L, Arbilla S, Langer SZ (1981) Presynaptic modulation of the release of dopamine from the rabbit caudate nucleus: Differences between electrical stimulation amphetamine and tyramine. J Pharmacol Exp Ther 216:592–598
König JFR, Klippel RA (1963) The rat brain: A stereotaxic atlas. Williams and Wilkins, Baltimore
Langer SZ, Arbilla S, Galzin AM, Cantrill R (1983) Stereoselective blockade by sulpiride of the effects of dopamine agonists on the release of dopamine, noradrenaline and acetylcholine. Acta Pharmaceutica Suecica, 98–107
Lehmann J, Smith RV, Langer SZ (1983) Stereoisomers of apomorphine differ in affinity and intrinsic activity at presynaptic dopamine receptors modulating 3H-dopamine and 3H-acetylcholine release in slices of cat caudate. Eur J Pharmacol (in press)
Moore KE (1978) The actions of amphetamine on neurotransmitters: A brief review. Biol Psychiat 12:451–462
Paul SM, Hulihan-Giblin B, Skolnick P (1982) (+)-Amphetamine binding to rat hypothalamus: Relation to anorexic potency of phenylethylamines. Science 218:487–490
Scatton B (1982) Effect of dopamine agonists and neuroleptic agents on striatal acetylcholine transmission in the rat: Evidence against dopamine receptor multiplicity. J Pharmacol Exp Ther 220:197–202
Smith CB (1963) Enhancement by reserpine and α-methyl DOPA of the effects of (+)-amphetamine upon the locomotor activity of mice. J Pharmacol Exp Ther 142:343–350
Zivkovic B, Guidotti A, Costa E (1974) Effect of neuroleptics on striatal tyrosine hydroxylase: Changes in the affinity for the pteridine cofactor. Mol Pharmacol 10:727–735
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cantrill, R., Arbilla, S., Zivkovic, B. et al. Amphetamine enhances latent dopaminergic neurotransmission in the rat striatum. Naunyn-Schmiedeberg's Arch. Pharmacol. 322, 322–324 (1983). https://doi.org/10.1007/BF00508350
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00508350