Relationship between relaxation and cyclic GMP formation caused by nicorandil in canine mesenteric artery

  • Masao Endoh
  • Norio Taira
Short Communication

Summary

In the isolated canine mesenteric artery relaxation caused by nicorandil [N-(2-hydroxyethyl)nicotinamide nitrate ester; SG-75] in the presence of noradrenaline was accompanied by a concomitant elevation of cGMP level, whilst the cAMP level was not changed by the drug. The relaxation and cGMP level after the administration of nicorandil showed a good correlation. In this respect nicorandil is very similar to nitrogen oxide-containing vasodilators.

Key words

Cyclic GMP Vasodilation Nicorandil Mesenteric artery Dog 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Axelsson KL, Andersson RGG, Wikberg JES (1981) Correlation between vascular smooth muscle relaxation and increase in cyclic GMP induced by some organic nitro esters. Acta Pharmacol Toxicol 49:270–276Google Scholar
  2. Diamond J, Janis RA (1978) Increases in cyclic GMP levels may not mediate relaxant effects of sodium nitroprusside, verapamil and hydralazine in rat vas deferens. Nature (Lond) 271:472–473Google Scholar
  3. Endoh M, Yamashita S, Taira N (1982) Positive inotropic effect of amrinone in relation to cyclic nucleotide metabolism in the canine ventricular muscle. J Pharmacol Exp Ther 221:775–783Google Scholar
  4. Furukawa K, Itoh T, Kajiwara M, Kitamura K, Suzuki H, Ito Y, Kuriyama H (1981) Vasodilating actions of 2-nicotinamidoethyl nitrate on porcine and guinea-pig coronary arterles. J Pharmacol Exp Ther 218:248–259Google Scholar
  5. Gruetter CA, Gruetter DY, Lyon JE, Kadowitz PJ, Ignarro LJ (1981) Relationship between cyclic guanosine 3′:5′-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: Effects of methylene blue and methemoglobin. J Pharmacol Exp Ther 219:181–186Google Scholar
  6. Ito Y, Kitamura K, Kuriyama H (1980) Actions of nitroglycerine on the membrane and mechanical properties of smooth muscles of the coronary artery of the pig. Br J Pharmacol 70:197–204Google Scholar
  7. Itoh T, Furukawa K, Kajiwara M, Kitamura K, Suzuki H, Ito Y, Kuriyama H (1981) Effects of 2-nicotinamidoethyl, nitrate on smooth muscle cells and on adrenergic transmission in the guinea-pig and porcine mesenteric arteries. J Pharmacol Exp Ther 218:260–270Google Scholar
  8. Janis RA, Diamond J (1979) Relationship between cyclic nucleotide levels and drug-induced relaxation of smooth muscle. J Pharmacol Exp Ther 211:480–484Google Scholar
  9. Kukovetz WR, Holzmann S, Wurm A, Pöch G (1979) Evidence for cyclic GMP-mediated relaxant effects of nitro-compounds in coronary smooth muscle. Naunyn-Schmiedeberg's Arch Pharmacol 310:129–138Google Scholar
  10. Maruyama M, Satoh K, Taira N (1982) Effects of nicorandil and its congeners on musculature and vasculature on the dog trachea in situ. Arch Int Pharmacodyn Ther 258:260–266Google Scholar
  11. Sakai K, Ohba Y, Akima M, Kamiyama H, Hinohara Y, Nakano H (1980) Pharmacodynamic and metabolism studies on a new coronary vasodilator, N-(2-hydroxyethyl)nicotinamide nitrate (SG-75). Jpn J Pharmacol 30:881–890Google Scholar
  12. Schultz KD, Schultz K, Schultz G (1977) Sodium nitroprusside and other smooth muscle-relaxants increase cyclic GMP levels in rat ductus deferens. Nature 265:750–751Google Scholar
  13. Taira N, Satoh K, Yanagisawa T, Imai Y, Hiwatari M (1979) Pharmacological profile of a new coronary vasodilator drug, 2-nicotinamidoethyl nitrate (SG-75). Clin Exp Pharmacol Physiol 6:301–316Google Scholar
  14. Uchida Y, Yoshimoto N, Murao S (1978) Effect of 2-nicotinamidethyl nitrate (SG-75) on coronary circulation. Jpn Heart J 19:112–124Google Scholar
  15. Yanagisawa T, Naira N (1980) Effect of 2-nicotinamidoethyl nitrate (SG-75) on the membrane potential of left atrial muscle fibres of the dog: Increase in potassium conductance. Naunyn-Schmiedeberg's Arch Pharmacol 312:69–76Google Scholar

Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Masao Endoh
    • 1
  • Norio Taira
    • 1
  1. 1.Department of PharmacologyTohoku University School of MedicineSendaiJapan

Personalised recommendations