Relationship between relaxation and cyclic GMP formation caused by nicorandil in canine mesenteric artery

  • Masao Endoh
  • Norio Taira
Short Communication


In the isolated canine mesenteric artery relaxation caused by nicorandil [N-(2-hydroxyethyl)nicotinamide nitrate ester; SG-75] in the presence of noradrenaline was accompanied by a concomitant elevation of cGMP level, whilst the cAMP level was not changed by the drug. The relaxation and cGMP level after the administration of nicorandil showed a good correlation. In this respect nicorandil is very similar to nitrogen oxide-containing vasodilators.

Key words

Cyclic GMP Vasodilation Nicorandil Mesenteric artery Dog 


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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Masao Endoh
    • 1
  • Norio Taira
    • 1
  1. 1.Department of PharmacologyTohoku University School of MedicineSendaiJapan

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