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Die Bedeutung der Enzymhistochemie in der Diagnostik sekundärer Hautcarcinome

The significance of enzyme histochemistry in the diagnosis of secondary carcinomas of the skin

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Summary

36 malignancies of different organs and 22 metastases were investigated enzyme-histochemically (12 enzymes) and the enzymatic reaction patterns were compared. The following observations were made:

  1. 1.

    Carcinomas of the same organ and the same histologic type generally exhibit the same enzymatic reaction pattern. The enzyme patterns of the corresponding primary and secondary (metastatic) tumors are identical.

  2. 2.

    Carcinomas of different organs show different enzymatic reaction patterns and so do their respective metastases.

Thus, it was possible to distinguish, histochemically, between skin metastases of various internal neoplasms. In some instances the enzyme-histochemical behaviour of a secondary malignancy of the skin is so characteristic as to give important diagnostic clues regarding the nature and site of the primary neoplasm.

Zusammenfassung

36 Primärtumoren verschiedener Organe und 22 Metastasen wurden mit enzymhistochemischen Methoden (insgesamt 12 Enzyme) untersucht. Die enzymatischen Reaktionsmuster wurden verglichen. Dabei konnte festgestellt werden:

  1. 1.

    Carcinome des gleichen Organs weisen bei gleichem histologischem Typ im allgemeinen ein gleichartiges enzymatisches Verhalten auf. Primärtumor und Metastase zeigen ein identisches enzymatisches Reaktionsmuster.

  2. 2.

    Carcinome verschiedener Organe unterscheiden sich in ihrem enzymatischen Verhalten, wobei sich dieselben Unterschiede auch in den Reaktionen der entsprechenden Metastasen finden.

Es war daher möglich Hautmetastasen verschiedener innerer Carcinome enzymhistochemisch von einander zu unterscheiden. In manchen Fällen ist das Reaktionsmuster einer Hautmetastase so charakteristisch, daß daraus auf die Art und den Sitz des Primärtumors geschlossen werden kann.

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Authors and Affiliations

  1. I. Universitäts-Hautklinik, Wien

    W. Wlk, K. Wolff & K. Holubar

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  1. W. Wlk
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  2. K. Wolff
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  3. K. Holubar
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Additional information

Herrn Prof. Dr. J. Tappeiner zum 60. Geburtstag gewidmet.

Mit Unterstützung durch den Fonds zur Förderung der wissenschaftlichen Forschung, Wien, und die Schering AG, Berlin.

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Wlk, W., Wolff, K. & Holubar, K. Die Bedeutung der Enzymhistochemie in der Diagnostik sekundärer Hautcarcinome. Arch. klin. exp. Derm. 236, 315–328 (1970). https://doi.org/10.1007/BF00508330

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  • DOI: https://doi.org/10.1007/BF00508330

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