Summary
The interaction of fusidic acid and two of its conjugates with carrier-mediated uptake of bile acids was investigated in isolated rat hepatocytes. All three fusidates inhibited the uptake of both cholate and taurocholate competitively suggesting a direct interaction of fusidates with bile acid carrier. The inhibition constants for all three fusidates for the inhibition of cholate uptake were significantly different from the respective inhibition constants for the inhibition of taurocholate uptake. This would indicate that both cholate and taurocholate are transported by more than one carrier into hepatocytes. The results may also indicate that taurine conjugated bile acids may be transported preferentially by one transport system while unconjugated bile acids may be preferentially transported by another transport system.
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Part of this publication was presented in the 18. Frühjahrstagung der Deutschen Pharmakologischen Gesellschaft (1977)
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Anwer, M.S., Hegner, D. Interaction of fusidates with bile acid uptake by isolated rat hepatocytes. Naunyn-Schmiedeberg's Arch. Pharmacol. 302, 329–332 (1978). https://doi.org/10.1007/BF00508303
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DOI: https://doi.org/10.1007/BF00508303