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Quantitative Bestimmung des Gewebsaktivators der Fibrinolyse in gesunder und kranker Haut

  • U. -F. Haustein
Article

Zusammenfassung

Mit Hilfe der KSCN-Extraktionsmethode wurde der Gewebsaktivatorgehalt normaler, entzündlich und tumorös veränderter Haut untersucht. Auf Grund der Ergebnisse gehörte die Haut zu den Geweben mit mittelstarker fibrinolytischer Aktivität. Parakeratotische Schuppen der Psoriasis vulgaris erwiesen sich im Gegensatz zu orthokeratotischen Schuppen der Ichthyosis congenita mit fehlendem fibrinolytischen Potential als stark aktiv, während die Extrakte aus psoriatisch veränderter Haut Normalwerte aufwiesen. Die bei chronisch entzündlichen Dermatosen (chronisches Ekzem) erniedrigte Aktivität wurde mit dem Fehlen von Gewebsaktivatoren in den Zellen des entzündlichen Infiltrates erklärt. Daraus wurde die Unzweckmäßigkeit einer antifibrinolytischen Therapie bei derartigen Dermatosen gefolgert. Die Erniedrigung der fibrinolytischen Aktivität bei verschiedenen Hauttumoren (Fibrom, Keratoakanthom) und ihre Erhöhung bei Plattenepithelcarcinomen wurde in Hinblick auf den Reifegrad der Tumorzellen sowie die in der Literatur referierten Wechselbeziehungen zwischen Tumor und umgebenden Stroma diskutiert. Viele Tumorarten (Naevuszellnaevus, Verruca seborrhoides, Basaliom) entwickelten jedoch eine normale Aktivität. Subcutanes Fettgewebe zeigte eine deutlich herabgesetzte fibrinolytische Aktivität. Offenbar kommt der lokalen Fibrinolyse bei den untersuchten Dermatosen und Hauttumoren keine entscheidende pathogenetische Bedeutung zu.

Quantitative estimation of the tissue activator of fibrinolysis in normal and pathologically changed skin

Summary

The content of tissue activator of the normal and inflammatory changed human skin and skin tumors was investigated by means of the KSCN-extraction method. According with the results the skin belonged to tissues with middle high fibrinolytic activity. The parakeratotic scales from the skin of psoriasis vulgaris were very active in contrast to the orthokeratotic scales from the skin of ichthyosis congenita where activity was absent. Extracts from psoriatic skin exhibited normal values. The diminished activity in chronic inflammatory dermatoses (chronic eczema) was explained by the absence of the tissue activators in the cells of the inflammatory infiltrats. Therefrom the unsuitableness of an antifibrinolytic therapy in such dermatoses was concluded. The diminution of fibrinolytic activity in several skin tumors (fibroma, keratoacanthoma) and its enhancement in squamous cell carcinoma was discussed in view of the degree of maturation of the tumor cells and of the relations refered in the literature between tumor and surrounding stroma. Many kinds of tumors (nevus cell nevus, basal cell papilloma, basal cell carcinoma) produced a normal activity. The subcutaneous fatty tissue showed a clearly diminished fibrinolytic activity. The local fibrinolysis apparently has no decisive pathogenetic importance in the investigated dermatoses and skin tumors.

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© Springer-Verlag 1968

Authors and Affiliations

  • U. -F. Haustein
    • 1
  1. 1.Klinik und Poliklinik für Hautkrankheiten der Friedrich Schiller-Universität JenaJenaDeutschland

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