Summary
Phenoxybenzamine, FLA-63 and α-MT produced less locomotor depression in mice withdrawn for 4 days from a 21 day treatment with haloperidol than that produced in vehicle-treated animals. There were no differences between the two groups when challenged with yohimbine or phentolaminé. The data support the hypothesis that central α-adrenergic receptors had become supersensitive and suggest that the sensitivity changes are restricted to post-synaptic receptors.
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Dunstan, R., Jackson, D.M. Further evidence for a change in central α-adrenergic receptor sensitivity after withdrawal from long-term haloperidol treatment. Naunyn-Schmiedeberg's Arch. Pharmacol. 303, 153–156 (1978). https://doi.org/10.1007/BF00508061
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DOI: https://doi.org/10.1007/BF00508061