Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 306, Issue 3, pp 209–211 | Cite as

The affinity of atropine for muscarine receptors in human sphincter pupillae

  • A. J. Kaumann
  • R. Hennekes


Concentration-dependent contractions in response to carbachol were determined on isolated pieces of human iris. Atropine competitively antagonized the effect of carbachol. An apparent dissociation equilibrium constant of 0.4–0.7 nM was estimated for the muscarine receptor-atropine complex.

Key words

Isolated human iris Carbachol Atropine Muscarine receptor 


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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • A. J. Kaumann
    • 1
  • R. Hennekes
    • 2
  1. 1.Lehrstuhl für Klinische PhysiologiePhysiologisches Institut der UniversitätDüsseldorfFederal Republic of Germany
  2. 2.UniversitätsaugenklinikDüsseldorfFederal Republic of Germany

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