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Mass spectra of substituted 4-aminopiperidines with a shielded nitrogen atom

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The principal fragmentation pathway of 4-aminopiperidines under the influence of electron impact are determined by charge localization on the nitrogen atom of the piperidine ring or on the nitrogen atom of the substituent in the 4 position. In the case of electron-donor substituents in the 4 position and in the absence of a substituent attached to the nitrogen atom of the polysubstituted piperidine ring the charge is primarily localized on the nitrogen atom of the substituent; this is expressed in the specific fragmentation pathways. The principles found in this research make it possible to establish the structures of nitrogen-containing compounds that are similar to the investigated compounds.

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Authors and Affiliations

  1. S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical Chemistry, 119021, Moscow

    A. I. Ermakov & Yu. N. Sheinker

Authors
  1. A. I. Ermakov
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  2. Yu. N. Sheinker
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Additional information

Communication 10 in the series “Application of mass spectrometry in structural and stereochemical studies.” See [1] for Communication 9.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 72–77, January, 1981.

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Ermakov, A.I., Sheinker, Y.N. Mass spectra of substituted 4-aminopiperidines with a shielded nitrogen atom. Chem Heterocycl Compd 17, 58–63 (1981). https://doi.org/10.1007/BF00507093

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  • DOI: https://doi.org/10.1007/BF00507093

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