Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 301, Issue 3, pp 237–240 | Cite as

Muscle relaxant properties of the identified metabolites of dantrolene

  • K. O. Ellis
  • F. L. Wessels
Article

Summary

Identified metabolites of dantrolene, a skeletal muscle relaxant, were studied for inhibition of skeletal muscle contractions. Inhibition of muscle contractions were studied in vivo in the rat gastrocnemius muscle preparation, and in vitro using isolated rat diaphragm strips. Dantrolene (D) and 5-hydroxydantrolene (5-HD) inhibited muscle contraction responses in a dose dependent manner, both in vivo and in vitro. 5-HD was less potent than D.

Key words

Dantrolene Skeletal muscle relaxant 5-Hydroxydantrolene 

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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • K. O. Ellis
    • 1
  • F. L. Wessels
    • 1
  1. 1.Division of Morton-Norwich Products, Inc.Scientific Affairs Department, Norwich-Eaton PharmaceuticalsNorwichUSA

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