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Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 301, Issue 3, pp 181–185 | Cite as

Inhibition by opiate narcotics of rat flexor α-motoneurones

  • U. Seeber
  • K. Kuschinsky
  • K.-H. Sontag
Article

Summary

Specific effects of opiate narcotics on rat flexor α-motoneurones were studied in ventral roots of laminectomized rats under halothane anaesthesia. The α-motoneurones were activated by tetanic stimulation of the cut ipsilateral common peroneal nerve, exciting up to group II- but not group III- and C-afferents. Morphine (0.5–3.0 mg/kg i.v.) reduced or completely suppressed the discharge rate of flexor α-motoneurones in a dose-dependent manner. This effect was antagonized by naloxone (0.5 mg/kg i.v.) and mimicked by levorphanol (1.0 mg/kg i.v.), but not by an equal dose of its steroisomer dextrorphan, suggesting that the effect described is a specific one. After spinalization, the inhibitory effect of morphine was abolished. Previous studies had shown that opiates (e.g. morphine, given in a dose of 2 or 4 mg/kg i.v.) excite rat extensor α-motoneurones, an effect opposite to the opiate narcotic action on flexor α-motoneurones. The action of opiates leading to an inhibition of flexor α-motoneurones may contribute to akinesia and catalepsy, and opioid-induced muscular rigidity. From the results presented it appears that morphine produces a reciprocal change in the activity evoked in extensor and flexor reflex pathways.

Key words

Motoneurones Flexor α-motoneurones Opiate narcotics Morphine Naloxone 

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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • U. Seeber
    • 1
  • K. Kuschinsky
    • 1
  • K.-H. Sontag
    • 1
  1. 1.Institut für Biochemische PharmakologieMax-Planck-Institut für Experimentelle MedizinGöttingenFederal Republic of Germany

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