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Hypersensitivity towards alpha-crystalline in the heterochromia syndrome

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Summary

In 4 cases of heterochromic cyclitis with cataract, 5 cases of herpetic iridocyclitis, and 5 cases of senile cataract, hypersensitivity to both alpha-crystalline and uveal pigment was investigated by lymphocyte-transformation and leukocyte-migration tests. In 3 cases of heterochromic cyclitis with cataracts, cellular hypersensitivity to alpha-crystalline was proven. Basing on these findings, the role of hypersensitivity to lens proteins in the etiology of heterochromic cyclitis is suggested.

Zusammenfassung

Mit Hilfe des Lymphocyten-Transformations- und des Leukocyten-Migrations-Testes wurden vier Patienten mit durch Cataract komplizierter Heterochromiecyclitis, fünf Patienten mit herpetischer Iridocyclitis und fünf Patienten mit Cataracta senilis auf eine Überempfindlichkeit gegenüber alpha-Crystallin sowie Uveapigment geprüft. Im Laufe der Untersuchungen konnte bei drei Patienten mit durch Cataract komplizierter Heterochromiecyclitis eine Überempfindlichkeit cellulären Typs gegenüber alpha-Crystallin nachgewiesen werden. Aufgrund dieser Ergebnisse ist anzunehmen, daß bei der Entstehung der Heterochromiecyclitis eine Autosensibilisierung gegenüber Linseneiweiß eine ätiologische Rolle spielen kann.

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Authors and Affiliations

  1. Department of Ophthalmology, University Medical School, Szeged

    Helga Hammer & M. Olah

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  1. Helga Hammer
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  2. M. Olah
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Hammer, H., Olah, M. Hypersensitivity towards alpha-crystalline in the heterochromia syndrome. Albrecht von Graefes Arch. Klin. Ophthalmol. 197, 61–66 (1975). https://doi.org/10.1007/BF00506642

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  • DOI: https://doi.org/10.1007/BF00506642

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