Summary
Three groups of European hamster (EH) (Cricetus cricetus L.) were treated subcutaneously every two weeks for life with 1/10 or 1/20 LD50 DMH, while two other groups served as controls. Twelve weeks after commencement of treatment, radiological examinations of the colon and rectum were begun. The double contrast method was used. In this way it was possible to detect the earliest neoplastic alteration to take place in the above sites. This occurred in the 26th treatment week and was diagnosed as an adenocarcinoma. The technique used is simple, as well as being suitable for large numbers of animals. In addition, it allows for early experimental analysis of results in respect to latency period, growth rate, incidence and location of tumours.
Zusammenfassung
Drei Gruppen Europäischer Hamster (EH) (Cricetus cricetus L.) wurden im Abstand von zwei Wochen lebenslang subcutan mit 1/10 oder 1/20 der LD50 DMH behandelt. Zwei andere Gruppen dienten als Kontrollen. Zwölf Wochen nach Behandlungsbeginn begann die radiologische Untersuchung von Colon und Rectum. Zur Darstellung wurde die Doppelkontrastmethode bevorzugt. Mit dieser Technik wurden frühe Veränderungen schon nach 26 Wochen entdeckt. Die Methode ist einfach in der Anwendung und kann bei großen Tierzahlen angewandt werden. Zusätzlich können Aussagen über Latenzzeit, Wachstumsgeschwindigkeit und Lokalisation von Tumoren im Darmbereich gemacht werden.
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Reznik, G., Eckel, H., Green, U. et al. Early X-ray detection of colonic and rectal tumours in European hamsters. Z. Krebsforsch. 87, 321–326 (1976). https://doi.org/10.1007/BF00506505
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DOI: https://doi.org/10.1007/BF00506505