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Recyclization of 5-carbethoxy-4-methyl-2-mercapto(amino, hydroxy) pyrimidines to give 5-acetyl-2-mercapto(amino, hydroxy)-4-hydroxypyrimidines

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Conditions for the selective preparation of 5-carbethoxy-4-methyl-2-substituted pyrimidines or 5-acetyl-4-hydroxy-2-substituted pyrimidines by condensation of ethoxymethyleneacetoacetic ester with 1,3-binucleophiles are proposed. It is shown that under the influence of sodium ethoxide 5-carbethoxy-4-methyl-2-substituted pyrimidines undergo rearrangement to 5-acetyl-4-hydroxy-2-substituted pyrimidines.

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Authors and Affiliations

  1. A. L. Mndzhoyan Institute of Fine Organic Chemistry, Academy of Sciences of the Armenian SSR, Erevan

    R. S. Vartanyan, Zh. V. Kazaryan & S. A. Vartanyan

Authors
  1. R. S. Vartanyan
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  2. Zh. V. Kazaryan
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  3. S. A. Vartanyan
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Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1558–1559, November, 1982.

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Vartanyan, R.S., Kazaryan, Z.V. & Vartanyan, S.A. Recyclization of 5-carbethoxy-4-methyl-2-mercapto(amino, hydroxy) pyrimidines to give 5-acetyl-2-mercapto(amino, hydroxy)-4-hydroxypyrimidines. Chem Heterocycl Compd 18, 1212–1213 (1982). https://doi.org/10.1007/BF00506377

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  • DOI: https://doi.org/10.1007/BF00506377

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