Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 320, Issue 2, pp 201–204 | Cite as

The effects of molsidomine on intracranial pressure in anaesthetized dogs

  • Volker B. Fiedler
  • Sybille Buchheim
  • Josef Scholtholt
Short Communication

Summary

Measurements of intracranial liquor pressure were made during i.v. molsidomine administration in pentobarbital anaesthetized beagle dogs without thoracotomy, and compared with those after nitroglycerin. The administration of 100 μg/kg molsidomine decreased blood pressure by 14 mmHg and increased intracranial pressure by 3.7 cm H2O (p<0.05). No changes in heart rate and the alveolar endtidal CO2 concentration were noted. The i.v. administration of 5 μg/kg nitroglycerin, however, decreased systolic blood pressure by 41 mmHg (p<0.05), increased heart rate by 40 bpm (p<0.01), elevated intracranial pressure by 3.2 cm H2O (p<0.05), and caused marked hyperventilation indicated by increased end-tidal CO2 concentration. Larger increases in intracranial pressure were related to larger pressure reductions. Thus, molsidomine produced significant increase in intracranial liquor pressure of longer duration (60 to 90 min of observation time). Nitroglycerin increased liquor pressure with a short duration of action and was about twenty times more effective with respect to intracranial pressure increase. In contrast to molsidomine, this was accompanied by significant decrease in systolic peripheral blood pressure.

Key words

Molsidomine Nitroglycerin Intracranial liquor pressure Blood pressure Canine experiments 

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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Volker B. Fiedler
    • 1
  • Sybille Buchheim
    • 1
  • Josef Scholtholt
    • 1
  1. 1.Abteilung für Cardiovasculäre PharmakologieMedizinische und Biologische Forschung der Cassella AGFrankfurt/Main 61Germany

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