Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 320, Issue 2, pp 201–204 | Cite as

The effects of molsidomine on intracranial pressure in anaesthetized dogs

  • Volker B. Fiedler
  • Sybille Buchheim
  • Josef Scholtholt
Short Communication


Measurements of intracranial liquor pressure were made during i.v. molsidomine administration in pentobarbital anaesthetized beagle dogs without thoracotomy, and compared with those after nitroglycerin. The administration of 100 μg/kg molsidomine decreased blood pressure by 14 mmHg and increased intracranial pressure by 3.7 cm H2O (p<0.05). No changes in heart rate and the alveolar endtidal CO2 concentration were noted. The i.v. administration of 5 μg/kg nitroglycerin, however, decreased systolic blood pressure by 41 mmHg (p<0.05), increased heart rate by 40 bpm (p<0.01), elevated intracranial pressure by 3.2 cm H2O (p<0.05), and caused marked hyperventilation indicated by increased end-tidal CO2 concentration. Larger increases in intracranial pressure were related to larger pressure reductions. Thus, molsidomine produced significant increase in intracranial liquor pressure of longer duration (60 to 90 min of observation time). Nitroglycerin increased liquor pressure with a short duration of action and was about twenty times more effective with respect to intracranial pressure increase. In contrast to molsidomine, this was accompanied by significant decrease in systolic peripheral blood pressure.

Key words

Molsidomine Nitroglycerin Intracranial liquor pressure Blood pressure Canine experiments 


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  1. Aptecar M, Otero y Garzon CA, Vasquez A, Varini S, Collia L, Esteguy A, Caruso S (1981) Hemodynamic effecs of molsidomine vasodilator therapy in acute myocardial infarction. Am Heart J 101:369–373Google Scholar
  2. Chestnut JS, Albin MS, Gonzalez-Abola E et al. (1978) Clinical evaluation of intravenous nitroglycerin for neurosurgery. J Neurosurg 48:704–711Google Scholar
  3. Dunnett CW (1964) New tables for multiple comparisons with a control. Biometrics 20:482–491Google Scholar
  4. Fiedler VB, Scholtholt J (1978) Haemodynamic effects of molsidomine. Arzneim Forsch 28:1605–1612Google Scholar
  5. Fiedler VB, Nitz RE (1981) Effects of molsidomine, nitroglycerin, and isosorbide dinitrate on the coronary circulation, myocardial oxygen consumption, and haemodynamics in anaesthetized dogs. Naunyn-Schmiedeberg's Arch Pharmacol 317:71–77Google Scholar
  6. Higgins CB, Vatner SF, Franklin D, Braunwald E (1973) Extent of regulation of the heart's contractile state in the conscious dog by alteration in the frequency of contraction. J Clin Invest 52:1187–1194Google Scholar
  7. Holtz J, Bassenge E, Kolin A (1978) Hemodynamic and myocardial effects of long-lasting venodilation in the conscious dog. Analysis of molsidomine in comparison with nitrates. Basic Res Cardiol 73:469–481Google Scholar
  8. Majid PA, DeFeyter PJF, van der Wall EE, Wardeh R, Roos JP (1980) Molsidomine in the treatment of patients with angina pectoris. Acute hemodynamic effects and clinical efficacy. N Engl J Med 302:1–6Google Scholar
  9. Rogers MC, Traystman RJ (1979) Nitroglycerin and nitroprusside induced changes in cerebral hemodynamics. Anesthesiology 51:S199Google Scholar
  10. Rogers MC, Hamburger C, Owen K, Epstein MH (1979) Intracranial pressure in the cat during nitroglycerin-induced hypotension. Anesthesiology 51:227–229Google Scholar
  11. Sadoshima S, Thames M, Heistad D (1981) Cerebral blood flow during elevation of intracranial pressure: role of sympathetic nerves. Am J Physiol 241:H78-H84Google Scholar
  12. Scholtholt J, Fiedler VB, Keil M (1978) Die Wirkung von Molsidomin auf die regionale Verteilung des Herzminutenvolumens des narkotisierten Hundes. Arzneim Forsch 28:1612–1619Google Scholar
  13. Stetson JB (1978) Intravenous nitroglycerin: A review. Int Anesthesiol Clin 16:261–298Google Scholar
  14. Tanayama S, Nakai Y, Fujita T, Suzuoki Z, Imashiro Y, Masuda K (1974) Biotransformation of molsidomine (N-ethoxycarbonyl-3-morpholinosydnonimine), a new anti-anginal agent, in rats. Xenobiotica 4:175–191Google Scholar
  15. Vatner SF (1978) Effects of anesthesia on cardiovascular control mechnisms. Environment Health Perspect 26:193–206Google Scholar
  16. Yeager JC, Haddy FJ (1977) The effects of thoracotomy on coronary blood flow in the dog. J Thor Cardiovasc Surg 74:907–912Google Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Volker B. Fiedler
    • 1
  • Sybille Buchheim
    • 1
  • Josef Scholtholt
    • 1
  1. 1.Abteilung für Cardiovasculäre PharmakologieMedizinische und Biologische Forschung der Cassella AGFrankfurt/Main 61Germany

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