Summary
The bioflavonoid quercetin is a potent inhibitor of a cyclic nucleotide-independent, tumor virus-coded protein kinase which phosphorylates tyrosine residues and acts as a cellular transforming protein. Half-maximal inhibition of the protein kinase occurred at 3–4 μM quercetin whereas rutin was much less effective. The finding, that quercetin inhibits a cyclic nucleotide-independent protein kinase activity, may provide clues to the diverse pharmacological effects of the bioflavonoids.
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Glossmann, H., Presek, P. & Eigenbrodt, E. Quercetin inhibits tyrosine phosphorylation by the cyclic nucleotide-independent, transforming protein kinase, pp60src . Naunyn-Schmiedeberg's Arch. Pharmacol. 317, 100–102 (1981). https://doi.org/10.1007/BF00506266
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DOI: https://doi.org/10.1007/BF00506266