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Intracardiac electric stimulation in conscious rabbits

A new model for screening membrane-stabilizing antiarrhythmics

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Summary

Cardiac arrhythmics were induced in conscious rabbits by intracardiac electric stimulation. The arrhythmic threshold remained constant for a period of more than 6 months. The antiarrhythmic drugs ajmaline, prajmalium, disopyramide, quinidine, lidocaine, propranolol and verapamil, given i.v. or orally, were screened for their thresholdraising potency. Particularly the membrane-stabilizing antiarrhythmics showed significant effects. The model may constitute a useful screen for such drugs in the conscious animal.

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References

  • Anttila M, Tikkanen R, Nieminen L (1978) Pharmacokinetic studies of the antiarrhythmic drugs ajmaline and N-propylajmaline bitartrate in dogs. Arzneim Forsch (Drug Res) 28:397–399

    Google Scholar 

  • Diederich KW, Beeck J (1970) Quantitative Vergleichsuntersuchungen zur Änderung der ventrikulären Flimmerschwelle durch antifibrillatorische Substanzen Z Kreislaufforschg 59:736–743

    Google Scholar 

  • Ellis CH (1956) Screening of drugs for antiarrhythmic activity. Ann NY Acad Sci 64:552–563

    Google Scholar 

  • Franke H (1977) Therapie und Nachsorge bei Patienten mit Herzrhythmusstörungen. Pharmaz Ztg 122:476–477

    Google Scholar 

  • Hackenberger F (1979) Antiarrhythmica. Pharmazie 34:491–500

    Google Scholar 

  • Heinz N (1971) Beeinflussung der distolischen Reizschwelle des menschlichen Herzens durch Antiarrhythmika. Arzneim Forsch (Drug Res) 21:1189–1191

    Google Scholar 

  • Höhler H, Benz J (1975) Reizschwellenverhalten nach Herzschrittmacher-Implantation unter besonderer Berücksichtigung der Elektrodendislokation. Dtsch Med Wochenschr 100:2150–2156

    Google Scholar 

  • Johnson EA (1954) The effect of antifibrillatory drugs on the cat's heart in vivo. Br J Pharmacol 9:341–345

    Google Scholar 

  • Karim A (1975) The pharmakokinetics of Norpace. Angiology 26 (Suppl 1): 85–98

    Google Scholar 

  • Kirsch U (1969) Bestimmung der Flimmerschwelle des Meerschweinchenherzens bei Spontanatmung mittels einer intracardialen Elektrode. Arzneim Forsch (Drug Res) 19:225–228

    Google Scholar 

  • Lillie Ch, Kobinger W (1978) Pharmakologische Differenzierung verschiedener Antiarrhythmika im Tierversuch. In: Hitzenberger G, Flener R (eds) „Moderne Antiarrhythmika; Fortschritte der klinischen Pharmakologie”, Vol 16. Urban and Schwarzenberg, München, pp 3–16

    Google Scholar 

  • Mertens HM, Schelbert HR, Kreuzer H, Spiller P, Schmiel FK (1973) Wirkung von N-(n-Propyl)-ajmalinium-hydrogentartrat auf die Hämodynamik des Hundes. Arzneim Forsch (Drug Res) 23:642–645

    Google Scholar 

  • Opie LH (1980) Drugs and the heart. III. Calcium antagonists. Lancet 8173:806–810

    Google Scholar 

  • Ostle B (1963) Statistics in research. Iowa State University Press

  • Petter A, Zipf K (1962) Zur antifibrillären Herzwirkung von Ajmalin, Brom-Ajmalin, Chinidin und Novocainamid. Naunyn-Schmiedebergs Arch Exp Path Pharmak 243:519–527

    Google Scholar 

  • Rohte O (1977) Vergleichende Untersuchungen von antiarrhythmisch wirksamen Pharmaka in verschiedenen tierexperimentellen Modellen. Habilitationsschrift, Tierärztliche Hochschule, Hannover

    Google Scholar 

  • Rohte O, Thormählen D (1980) Die Wirkung von Antiarrhythmika im Experiment und in der Praxis. Der Prakt Tierarzt 61:568–573

    Google Scholar 

  • Schaumlöffel E (1974) Pharmakokinetische Studien mit radioaktiv markiertem N-Propyl-ajmalinium-hydrogentartrat. Med Welt 25:2008–2014

    Google Scholar 

  • Summer M, Kalman MD (1978) Blood levels of drugs used in the treatment of cardiac arrhythmias. Clin Tox 13:567–585

    Google Scholar 

  • Szekeres L (1969) Prufung von antiarrhythmischen Substanzen. In: Förster W, Beierlein Ch (eds), „Herz- und kreislaufwirksame Pharmaka”. Kommissionsverlag Johann Ambrosius Barth. Leipzig, pp 13–41

    Google Scholar 

  • Szekeres L, Papp GJ (1971) Experimental cardiac arrhythmias and antiarrhythmic drugs. Akadémiai Kiadó, Budapest

    Google Scholar 

  • Szekeres L, Méhes J, Papp J (1961) Mechanisms of increased susceptibility to fibrillation of the hypothermic mammalian heart in situ. Br J Pharmacol 17:167–175

    Google Scholar 

  • v Philipsborn G (1968) N-(n-Propyl)ajmaliniumhydrogentartrat-Unter-suchungen über Toxizität und Pharmakologie. In: Holzmann M (ed) „Herzrhythmusstörungen — Neue experimentelle klinische und therapeutische Gesichtspunkte” F. K. Schattauer, Stuttgart New York, pp 123–141

    Google Scholar 

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Authors and Affiliations

  1. Abteilung für Experimentelle Forschung, Beecham-Wülfing, D-3212, Gronau, Federal Republic of Germany

    Dirk Thormählen & Oskar Rohte

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  1. Dirk Thormählen
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  2. Oskar Rohte
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Thormählen, D., Rohte, O. Intracardiac electric stimulation in conscious rabbits. Naunyn-Schmiedeberg's Arch. Pharmacol. 317, 81–85 (1981). https://doi.org/10.1007/BF00506262

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  • DOI: https://doi.org/10.1007/BF00506262

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