Chronotropic effects of pindolol
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The chronotropic effects of pindolol were studied in the conscious dog with chronic A-V block. Pindolol significantly increased atrial rate, probably through both its strong intrinsic sympathomimetic activity and reflex with-drawal of atrial vagal tone in response to its hypotensive effect. Pindolol did not alter ventricular rate overall. However, in individual dogs, pindolol caused ventricular chronotropic effects that were inversely related to resting ventricular rate: it increased ventricular rate when the resting ventricular rate was low and reduced it when it was high. In view of the fact that pindolol is a beta-adrenoceptor antagonist endowed with a strong intrinsic sympathomimetic activity, this finding contributes to a better understanding of how pindolol affects heart rate.
Key wordsConscious A-V blocked dogs Atrial rate Ventricular rate Pindolol
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- Aellig WH (1977) Investigations with beta-adrenoceptor blocking drugs in healthy volunteers. Acta Med Scand [Suppl 606] 202: 71–74Google Scholar
- Barrett AM, Carter J (1970) Comparative chronotropic activity of beta-adrenoceptive antagonists. Br J Pharmacol 40:373–381Google Scholar
- Bloomberg ML, Bergman H, Sheiner NM (1970) A technique of chronic arterial catheterization in dogs. J Cardiovasc Surg 11:137–140Google Scholar
- Boucher M, Duchêne-Marullaz P (1980) Acebutolol, metoprolol and propranolol in conscious dogs with chronic heart-block: chronotropic effects and relation between depression of ventricular activity and beta-adrenoceptor blocking potency. Br J Pharmacol 70:355–340Google Scholar
- Boucher M, Duchêne-Marullaz P, Lavarenne J (1979) Catecholamines and cardiac rhythms in the unanesthetized dog with chronic A-V block. Am J Physiol 237:H10-H17Google Scholar
- Boucher M, Dubray C, Duchêne-Marullaz P (1982) Long-term observation of atrial and ventricular rates in the unanesthetized dog with complete atrioventricular block. Pflügers Arch 395: 341–343Google Scholar
- Duchêne-Marullaz P, Combre A, Lavarenne J, Lapalus P, Schaff G (1975) Comparaison des effects du propranolol, de l'alprénolol, du pindolol et du practolol sur les rythmes cardiaques de chiens non narcosés en dissociation auriculo-ventriculaire chronique. J Pharmacol 6:441–452Google Scholar
- Fredericq L (1911) Dissociation par compression graduée des voies motrices et arrestatrices contenues dans le faisceau de His. Arch Int Physiol 11:405–417Google Scholar
- Man In't Veld AJ, Schalekamp MADH (1981) Pindolol acts as beta-adrenoceptor agonist in orthostatic hypotension: therapeutic implications. Br Med J 282:929–931Google Scholar
- Robinson JL, Farr WC, Grupp G (1973) Atrial rate response to ventricular pacing in the unanesthetized A-V blocked dog. Am J Physiol 224:40–45Google Scholar