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Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 325, Issue 2, pp 183–185 | Cite as

Chronotropic effects of pindolol

Relation between ventricular effect and control resting ventricular rate values in conscious dogs with chronic A-V block
  • Michel Boucher
  • Claude Dubray
  • Pierre Duchêne-Marullaz
Short Communication

Summary

The chronotropic effects of pindolol were studied in the conscious dog with chronic A-V block. Pindolol significantly increased atrial rate, probably through both its strong intrinsic sympathomimetic activity and reflex with-drawal of atrial vagal tone in response to its hypotensive effect. Pindolol did not alter ventricular rate overall. However, in individual dogs, pindolol caused ventricular chronotropic effects that were inversely related to resting ventricular rate: it increased ventricular rate when the resting ventricular rate was low and reduced it when it was high. In view of the fact that pindolol is a beta-adrenoceptor antagonist endowed with a strong intrinsic sympathomimetic activity, this finding contributes to a better understanding of how pindolol affects heart rate.

Key words

Conscious A-V blocked dogs Atrial rate Ventricular rate Pindolol 

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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • Michel Boucher
    • 1
  • Claude Dubray
    • 1
  • Pierre Duchêne-Marullaz
    • 1
  1. 1.Department of Pharmacology, U. 195 INSERMFaculty of MedicineClermont-Ferrand CédexFrance

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