Abstract
Derivatives of 8-methylquinoline-5-carboxylic acid were synthesized. Alcoholysis of 8-methyl-5-cyanoquinoline gave methyl and ethyl 8-methylquinoline-5-carboxylates, which were converted to the corresponding 8-bromomethyl derivatives. The latter were used for the introduction of a methylamino group and the synthesis of N-acyl derivatives. The hydrazide, amide, and anilide of 8-methylquinoline-5-carboxylic acid were obtained as model compounds.
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I. N. Gracheva and A. I. Tochilkin, Khim. Geterotsikl. Soedin., No. 3, 366 (1980).
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 785–788, June, 1982.
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Gracheva, I.N., Kovel'man, I.R. & Tochilkin, A.I. Synthesis of some bifunctional derivatives of 8-methylquinoline-5-carboxylic acid. Chem Heterocycl Compd 18, 594–597 (1982). https://doi.org/10.1007/BF00506150
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DOI: https://doi.org/10.1007/BF00506150