Abstract
4-R-5,6,7,8,9,10-Hexahydroimidazo [1,2,3-i,j] pteridinium chlorides and 4-R-7-(β-chloroethyl)-7,8-dihydroimidazo[1,2-c]pyrimidinium chlorides were obtained in the reaction of 6-R-5-amino-4-bis(β-hydroxyethyl) aminopyrimidines (R = H, Cl) with SOCl2 or POCl3. The pteridinium chlorides are formed through cyclization of the intermediately formed 4-R-8-(β-chloroethyl)-5,6,7,8-tetrahydropteridines, which, for R = Cl, were obtained independently by reduction of 4-chloro-6-bis-(β-chloroethyl) amino-5-nitropyrimidine. The conditions for the cyclization of imidazopyrimidinium chlorides to give imidazopteridinium chlorides were investigated.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1406–1413, October, 1983.
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Naumenko, I.I., Shishkin, G.V. Intramolecular cyclization of 5-amino-4-bis (β-chloroethyl)aminopyrimidines. Chem Heterocycl Compd 19, 1120–1127 (1983). https://doi.org/10.1007/BF00505771
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DOI: https://doi.org/10.1007/BF00505771