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Synthesis and transformations of 1-methyl-4-aryl-7-R-isoquinolines

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

1-Methyl-4-aryl-7-R-isoquinolines were obtained by cyclization of 1,1-diaryl-2-acetamidoethylenes in the presence of phosphorus pentoxide. The condensation of the products with diethyl oxalate leads to the formation of ethyl 1-(4-aryl-7-R-isoquinolyl)pyruvates, which react with o-phenylenediamine to give 1-(4-aryl-7-R-isoquinolyl)-2-[3-(4H)-oxo-2-quinoxalyl]methanes.

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Authors and Affiliations

  1. Institute of Continuum Mechanics, Ural Science Center, Academy of Sciences of the USSR, 614013, Perm

    V. S. Shklyaev, E. V. Dormidontova & R. F. Saraeva

  2. Perm State Pharmaceutical Institute, 614600, Perm

    V. S. Shklyaev, E. V. Dormidontova & R. F. Saraeva

Authors
  1. V. S. Shklyaev
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  2. E. V. Dormidontova
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  3. R. F. Saraeva
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Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1367–1369, October, 1983.

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Shklyaev, V.S., Dormidontova, E.V. & Saraeva, R.F. Synthesis and transformations of 1-methyl-4-aryl-7-R-isoquinolines. Chem Heterocycl Compd 19, 1088–1090 (1983). https://doi.org/10.1007/BF00505761

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  • DOI: https://doi.org/10.1007/BF00505761

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