Chemistry of Heterocyclic Compounds

, Volume 17, Issue 9, pp 869–871 | Cite as

New method for the reduction of benzofurans

  • L. N. Borisova
  • S. G. Rozenberg
  • N. F. Kucherova
  • V. A. Zagorevskii
Article

Abstract

A new method for the reduction of benzofurans with potassium and sodium borohydrides in CF3COOH was developed. It is shown by gas-liquid chromatography and PMR spectroscopy that mixtures (∼2∶3) of the cis and trans isomers of dihydro derivatives of benzofuran are formed in the reduction. The mechanism of the reduction includes intermolecular transfer of a hydride ion to the protonated form of the benzofuran.

Keywords

Sodium Spectroscopy Potassium Chromatography Organic Chemistry 

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Copyright information

© Plenum Publishing Corporation 1982

Authors and Affiliations

  • L. N. Borisova
    • 1
  • S. G. Rozenberg
    • 1
  • N. F. Kucherova
    • 1
  • V. A. Zagorevskii
    • 1
  1. 1.Scientific-Research Institute of PharmacologyAcademy of Medical Sciences of the USSRMoscow

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