Summary
The pretreatment of brain-cortex slices with mescaline does not affect tRNA or aminoacyl-tRNA synthetase, nor have the latter any role in the decreased amino acid incorporating ability of ribosomes of the drug-treated slices.
References
Brunngraber, E. F.: A simplified procedure for the preparation of soluble RNA from a rat liver. Biochem. biophys. Res. Commn. 8, 1–3 (1962)
Datta, R. K., Antopol, W.: Effect of chronic administration of morphine on mouse brain aminoacyl-tRNA synthetase and tRNA-amino acid binding. Brain Res. 53, 373–386 (1973)
Datta, R. K., Antopol, W., Ghosh, J. J.: Mescaline-induced changes of brain-cortex ribosomes. Effects of mescaline on ribosomal synthesis of poly-uridine-directed polyphenylalanine. Naunyn-Schmiedeberg's Arch. Pharmacol. 277, 319–322 (1973)
Datta, R. K., Ghosh, J. J.: Preparation and properties of brain-cortex ribosomes. J. Neurochem. 10, 363–372 (1963)
Datta, R. K., Ghosh, J. J.: Mescaline-induced changes of brain-cortex ribosomes. Effect of mescaline on the stability of brain-cortex ribosomes. Biochem. J. 117, 961–968 (1970)
Datta, R. K., Ghosh, J. J.: Mescaline-induced changes of brain-cortex ribosomes. Effect of mescaline on amino acid incorporating ability of ribosomes. Brain Res. 33, 193–203 (1971)
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The study was supported by the Saul Singer Foundation, the Charles H. Silver Fund, and the Lenore Weinstein Fund, New York. The author thanks Steven Friedfeld, Richard Seelig, Victoria Dixon and Caryl Towner for able assistance.
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Datta, R.K. Mescaline-induced changes of brain-cortex ribosomes. Naunyn-Schmiedeberg's Arch. Pharmacol. 280, 107–111 (1973). https://doi.org/10.1007/BF00505360
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DOI: https://doi.org/10.1007/BF00505360